Sleep and Breathing

, Volume 20, Issue 4, pp 1355–1362 | Cite as

Short sleep duration is associated with increased risk of pre-hypertension and hypertension in Chinese early middle-aged females

  • Xun-ming Sun
  • Shun Yao
  • Shu-juan Hu
  • Zu-yun Liu
  • Ya-jun Yang
  • Zi-yu Yuan
  • Wei-min Ye
  • Li Jin
  • Xiao-feng Wang
Epidemiology • Original Article



The aim of this study is to investigate the relationship between sleep duration and hypertension in a middle-aged Chinese population.


Cross-sectional data of 20,505 individuals aged 35–64 years from Taizhou longitudinal study was used. Logistic regression models were used to calculate odds ratios (ORs) for the risk of pre-hypertension and hypertension in association with sleep duration.


Short sleep duration was associated with high systolic and diastolic blood pressure in comparison with sleep duration of 7–8 h in females. Short sleep duration was also associated with an increased risk of hypertension in females. Age-stratified analysis showed that as compared with sleep duration of 7–8 h, sleep duration <6 h increased risk of hypertension after controlling for multiple covariates with an OR of 1.766 (1.024–2.775) in early middle-aged females of 35–44 years. More importantly, sleeping less than 6 h is associated with increased risk of pre-hypertension in females of this age category, after controlling for multiple covariates with an OR of 1.769 (1.058–2.958).


Sleeping less than 6 h a day is associated with increased risk of pre-hypertension and hypertension in Chinese early middle-aged females. The high-risk populations require sufficient sleep, which could probably prevent the increased risk of pre-hypertension as well as hypertension.


Sleep duration Pre-hypertension Hypertension Middle-aged population Female 



This work was supported by the grants from the International cooperation project of Ministry of Science and Technology (2014DFA32830), the National Basic Research Program (2012CB944600), the National Natural Science Foundation (31171216), and the National Science & Technology Support Program (2011BAI09B00).

Compliance with ethical standards


The International cooperation project of Ministry of Science and Technology provided financial support in the form of (2014DFA32830) funding, the National Basic Research Program provided financial support in the form of (2012CB944600) funding, the National Natural Science Foundation provided financial support in the form of (31171216) funding, and the National Science & Technology Support Program provided financial support in the form of (2011BAI09B00) funding.

The sponsor had no role in the design or conduct of this research.

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Written informed consents were obtained from all participants prior to participation, and the Human Ethics Committee of School of Life Science of Fudan University approved the study.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Xun-ming Sun
    • 1
  • Shun Yao
    • 1
  • Shu-juan Hu
    • 1
  • Zu-yun Liu
    • 1
  • Ya-jun Yang
    • 2
  • Zi-yu Yuan
    • 2
  • Wei-min Ye
    • 3
  • Li Jin
    • 1
  • Xiao-feng Wang
    • 1
  1. 1.Unit of Epidemiology, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical SciencesFudan UniversityShanghaiChina
  2. 2.Taizhou Research Institute of Health SciencesTaizhouChina
  3. 3.Department of Medical Epidemiology and BiostatisticsKarolinska InstitutetStockholmSweden

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