Obstructive sleep apnea and urological comorbidities in males: a population-based study
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This study aimed to investigate associations between obstructive sleep apnea (OSA) and urological comorbidities using a large population-based dataset.
This cross-sectional study used the Taiwan Longitudinal Health Insurance Database 2005. We included 1236 males with OSA in the study group and 4944 males without OSA in the comparison group. Conditional logistic regressions were performed to examine relationships between OSA and urological comorbidities.
We found that patients with OSA had significantly greater prevalences of hypertrophy of the prostate (15.13 vs. 7.28 %), chronic prostatitis (4.37 vs. 2.16 %,), urinary incontinence (3.32 vs. 0.87 %), nocturia (2.02 vs. 0.61 %), erectile dysfunction (2.91 vs. 0.97 %), urinary calculi (12.06 vs. 6.80 %), and prostate cancer (0.97 vs. 0.40 %) than the comparison group. Additionally, the adjusted odds ratios in males with OSA for hypertrophy of prostate, chronic prostatitis, urinary incontinence, nocturia, erectile dysfunction, urinary calculi, and prostate cancer were 2.54 (95 % confidence interval (CI) 2.05~3.15), 1.95 (95 % CI 1.38~2.74), 4.13 (95 % CI 2.63~6.50), 3.54 (95 % CI 2.03~6.18), 2.95 (95 % CI 1.89~4.61), 1.89 (95 % CI 1.53~2.33), and 2.14 (95 % CI 1.03~4.43) than those without OSA, respectively.
This study concluded that males with OSA had higher odds ratios of hypertrophy of the prostate, chronic prostatitis, urinary incontinence, nocturia, erectile dysfunction, urinary calculi, and prostate cancer than comparison group.
KeywordObstructive sleep apnea Urology Comorbidity Prostatitis Prostate
Compliance with ethical standards
This study was exempted from full review by the institutional review board (IRB) after consulting with the director of National Defense Medical Center’s IRB, since the LHID2005 consists of de-identified secondary data released to the public for research purposes.
No funding was received for this research.
- 23.Pastore AL, Palleschi G, Ripoli A, Silvestri L, Maggioni C, Pagliuca G, Nobili Benedetti FM, Gallo A, Zucchi A, Maurizi A, Costantini E, Carbone A (2014) Severe obstructive sleep apnoea syndrome and erectile dysfunction: a prospective randomised study to compare sildenafil vs. nasal continuous positive airway pressure. Int J Clin Pract 68(8):995–1000. doi: 10.1111/ijcp.12463 CrossRefPubMedGoogle Scholar
- 24.Hoekema A, Stel AL, Stegenga B, van der Hoeven JH, Wijkstra PJ, van Driel MF, de Bont LG (2007) Sexual function and obstructive sleep apnea-hypopnea: a randomized clinical trial evaluating the effects of oral-appliance and continuous positive airway pressure therapy. J Sex Med 4(4 Pt 2):1153–1162. doi: 10.1111/j.1743-6109.2006.00341.x CrossRefPubMedGoogle Scholar
- 26.Merchant ML, Cummins TD, Wilkey DW, Salyer SA, Powell DW, Klein JB, Lederer ED (2008) Proteomic analysis of renal calculi indicates an important role for inflammatory processes in calcium stone formation. Am J Physiol Ren Physiol 295(4):F1254–F1258. doi: 10.1152/ajprenal.00134.2008 CrossRefGoogle Scholar