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Association between continuous positive airway pressure and circulating omentin levels in patients with obstructive sleep apnoea

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

Inflammation and oxidative stress play important roles in the pathogenesis of obstructive sleep apnoea syndrome (OSAS). Omentin is expressed in visceral adipose tissue and is associated with the inflammatory response. The aim of this study was to assess the relationship between OSAS and omentin based on a comparison of its serum levels at baseline and after 3 months of continuous positive airway pressure (CPAP) therapy.

Methods

Ninety-six newly diagnosed OSAS patients and 31 non-apnoeic controls were enrolled in this study. Blood samples were obtained in the morning after polysomnography. Within the OSAS group, 30 patients were started on CPAP therapy and then reassessed clinically, including a blood test for serum omentin and other biochemical analysis, at 3 months.

Results

Serum omentin levels were significantly lower in the OSAS group than in the control group (27.7 ± 7.6 and 42.5 ± 5.2 ng/mL, P < 0.001). In the subgroup analysis, omentin concentrations were significantly lower in patients with severe OSAS than in those with mild/moderate OSAS (P < 0.001). Circulating omentin levels were significantly correlated with the apnoea–hypopnoea index (AHI), mean SaO2, oxygen desaturation index, and serum C-reactive protein levels. Treatment with CPAP resulted in a significant increase in circulating omentin levels after 3 months, from 22.7 ± 1.4 to 41.2 ± 3.3 ng/mL (P < 0.001).

Conclusions

OSAS is associated with low serum omentin levels, and these levels can be reversed by effective CPAP treatment.

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References

  1. Committee A-DCS (1997) The international classification of sleep disorders. Diagnostic and Coding Manual, Ed 2

  2. Peker Y, Hedner J, Norum J, Kraiczi H, Carlson J (2002) Increased incidence of cardiovascular disease in middle-aged men with obstructive sleep apnea: a 7-year follow-up. Am J Respir Crit Care Med 166(2):159–165. doi:10.1164/rccm.2105124

    Article  PubMed  Google Scholar 

  3. Heitmann J, Ehlenz K, Penzel T, Becker HF, Grote L, Voigt KH, Peter JH, Vogelmeier C (2004) Sympathetic activity is reduced by nCPAP in hypertensive obstructive sleep apnoea patients. Eur Respir J 23(2):255–262

    Article  CAS  PubMed  Google Scholar 

  4. Yin J, Hou P, Wu Z, Nie Y (2015) Decreased levels of serum omentin-1 in patients with inflammatory bowel disease. Med Sci Monit 21:118–122. doi:10.12659/MSM.892081

    Article  PubMed  PubMed Central  Google Scholar 

  5. Yamawaki H, Tsubaki N, Mukohda M, Okada M, Hara Y (2010) Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels. Biochem Biophys Res Commun 393(4):668–672. doi:10.1016/j.bbrc.2010.02.053

    Article  CAS  PubMed  Google Scholar 

  6. El-Mesallamy HO, El-Derany MO, Hamdy NM (2011) Serum omentin-1 and chemerin levels are interrelated in patients with type 2 diabetes mellitus with or without ischaemic heart disease. Diabet Med 28(10):1194–1200. doi:10.1111/j.1464-5491.2011.03353.x

    Article  CAS  PubMed  Google Scholar 

  7. Zhong X, Zhang H-y, Tan H, Zhou Y, Liu F-l, Chen F-q, Shang D-y (2011) Association of serum omentin-1 levels with coronary artery disease. Acta Pharmacol Sin 32(7):873–878. doi:10.1038/aps.2011.26

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Jaikanth C, Gurumurthy P, Cherian KM, Indhumathi T (2013) Emergence of omentin as a pleiotropic adipocytokine. Exp Clin Endocrinol Diabetes 121(7):377–383. doi:10.1055/s-0033-1345123

    Article  CAS  PubMed  Google Scholar 

  9. Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14(6):540–545

    CAS  PubMed  Google Scholar 

  10. Berry RB BR, Gamaldo CE, Harding SM, Marcus CL, Vaughn BV (2012) for the American Academy of Sleep Medicine. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.0. www.aasmnet.org. Accessed 13 March 2014

  11. Kokturk O, Ciftci TU, Mollarecep E, Ciftci B (2005) Elevated C-reactive protein levels and increased cardiovascular risk in patients with obstructive sleep apnea syndrome. Int Heart J 46(5):801–809

    Article  CAS  PubMed  Google Scholar 

  12. Ryan S, Taylor CT, McNicholas WT (2009) Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome? Thorax 64(7):631–636. doi:10.1136/thx.2008.105577

    CAS  PubMed  Google Scholar 

  13. Schäffler A, Neumeier M, Herfarth H, Fürst A, Schölmerich J, Büchler C (2005) Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue. Biochim Biophys Acta 1732(1–3):96–102. doi:10.1016/j.bbaexp.2005.11.005

    Article  PubMed  Google Scholar 

  14. Yamawaki H, Kuramoto J, Kameshima S, Usui T, Okada M, Hara Y (2011) Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells. Biochem Biophys Res Commun 408(2):339–343. doi:10.1016/j.bbrc.2011.04.039

    Article  CAS  PubMed  Google Scholar 

  15. Moreno-Navarrete JM, Catalán V, Ortega F, Gómez-Ambrosi J, Ricart W, Frühbeck G, Fernández-Real JM (2010) Circulating omentin concentration increases after weight loss. Nutr Metab (Lond) 7:27. doi:10.1186/1743-7075-7-27

    Article  Google Scholar 

  16. Kurt OK, Tosun M, Alcelik A, Yilmaz B, Talay F (2014) Serum omentin levels in patients with obstructive sleep apnea. Sleep Breath 18(2):391–395. doi:10.1007/s11325-013-0898-0

    Article  PubMed  Google Scholar 

  17. Zirlik S, Hildner KM, Targosz A, Neurath MF, Fuchs FS, Brzozowski T, Konturek PC (2013) Melatonin and omentin: influence factors in the obstructive sleep apnoea syndrome? J Physiol Pharmacol 64(3):353–360

    CAS  PubMed  Google Scholar 

  18. Wang Q, Feng X, Zhou C, Li P, Kang J (2013) Decreased levels of serum omentin-1 in patients with obstructive sleep apnoea syndrome. Ann Clin Biochem 50(Pt 3):230–235. doi:10.1177/0004563212473275

    Article  PubMed  Google Scholar 

  19. Guo Y, Pan L, Ren D, Xie X (2013) Impact of continuous positive airway pressure on C-reactive protein in patients with obstructive sleep apnea: a meta-analysis. Sleep Breath 17(2):495–503. doi:10.1007/s11325-012-0722-2

    Article  PubMed  Google Scholar 

  20. Marin JM, Carrizo SJ, Vicente E, Agusti AGN (2005) Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 365(9464):1046–1053. doi:10.1016/s0140-6736(05)71141-7

    Article  PubMed  Google Scholar 

  21. Xie X, Pan L, Ren D, Du C, Guo Y (2013) Effects of continuous positive airway pressure therapy on systemic inflammation in obstructive sleep apnea: a meta-analysis. Sleep Med 14(11):1139–1150. doi:10.1016/j.sleep.2013.07.006

    Article  PubMed  Google Scholar 

  22. Garcia JM, Sharafkhaneh H, Hirshkowitz M, Elkhatib R, Sharafkhaneh A (2011) Weight and metabolic effects of CPAP in obstructive sleep apnea patients with obesity. Respir Res 12(1):80. doi:10.1186/1465-9921-12-80

    Article  PubMed  PubMed Central  Google Scholar 

  23. Ishida K, Kato M, Kato Y, Yanagihara K, Kinugasa Y, Kotani K, Igawa O, Hisatome I, Shigemasa C, Somers VK (2009) Appropriate use of nasal continuous positive airway pressure decreases elevated C-reactive protein in patients with obstructive sleep apnea. Chest 136(1):125–129. doi:10.1378/chest.08-1431

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Colish J, Walker JR, Elmayergi N, Almutairi S, Alharbi F, Lytwyn M, Francis A, Bohonis S, Zeglinski M, Kirkpatrick IDC, Sharma S, Jassal DS (2012) Obstructive sleep apnea: effects of continuous positive airway pressure on cardiac remodeling as assessed by cardiac biomarkers, echocardiography, and cardiac MRI. Chest 141(3):674–681. doi:10.1378/chest.11-0615

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, Kozlu/Zonguldak, 67600, Turkey

    Firat Uygur, Hakan Tanrıverdi, Fatma Erboy, Bulent Altınsoy, Figen Atalay, Tacettin Ornek & Meltem Tor

  2. Faculty of Medicine, Department of Biochemistry, Bulent Ecevit University, Zonguldak, Turkey

    Murat Can

  3. Faculty of Medicine, Department of Otolaryngology, Bulent Ecevit University, Zonguldak, Turkey

    Murat Damar

  4. Faculty of Medicine, Department of Biostatistics, Bulent Ecevit University, Zonguldak, Turkey

    Furuzan Kokturk

Authors
  1. Firat Uygur
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  2. Hakan Tanrıverdi
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  3. Murat Can
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  4. Fatma Erboy
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  5. Bulent Altınsoy
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  7. Tacettin Ornek
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  8. Murat Damar
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  9. Furuzan Kokturk
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Corresponding author

Correspondence to Firat Uygur.

Ethics declarations

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Funding

No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licencing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Comments

Obesity is a problem commonly associated with people diagnosed with obstructive sleep apnoea syndrome (OSAS). It is known that omentin expressed in visceral adipose tissue is associated with the inflammatory response, which in turn has role in the pathogenesis of OSAS. The results of this study which included 30 patients with moderate-severe OSAS treated with CPAP suggest that the therapy can positively influence serum omentin levels and thus have the potential to benefit vascular health, which is at risk in people with OSAS.

Margot Skinner

Dunedin, New Zealand

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Uygur, F., Tanrıverdi, H., Can, M. et al. Association between continuous positive airway pressure and circulating omentin levels in patients with obstructive sleep apnoea. Sleep Breath 20, 939–945 (2016). https://doi.org/10.1007/s11325-016-1315-2

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  • DOI: https://doi.org/10.1007/s11325-016-1315-2

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