Abstract
Purpose
Work-related stress factors are commonly considered to be increasing the risk of insomnia. But the association between circadian-rhythm gene period2 (per2) and insomnia remains unknown. The paper aimed to examine the relationships among the polymorphism in rs7602358 of Per2 gene, work stress, and insomnia.
Methods
In the cross-sectional study of a total of 364 Chinese workers recruited, 218 had insomnia tested by the Athens Insomnia Scale (AIS-5). Work stress was assessed using the General Job Stress Questionnaire (GJSQ). Per2 genotypes were determined by SNaPshot technology. Unconditional logistic regression analysis was used to examine the interaction between polymorphism of Per2 and work stress in insomnia.
Results
The genotype AC or allele C of Per2 significantly increased the risk of insomnia (OR, 5.41; 95 % CI, 2.23–13.1) (OR, 3.29; 95 % CI, 1.55–6.98). Compared to low work stress, high work stress had a higher risk of insomnia (OR, 2.73; 95 % CI, 1.77–4.22). A significant interaction between Per2 and work stress in the risk of insomnia was found. Compared to workers with low work stress and genotype AA, those with high work stress and genotype AC had a higher risk of insomnia (OR, 15.12; 95 % CI, 3.46–66.09).
Conclusions
The effect of genotype AC or allele C of Per2 on insomnia was relatively stronger than that of high work stress, suggesting that individual’s susceptibility should be taken into consideration when intervening and controlling insomnia of workers.
Similar content being viewed by others
References
Kessler RC, Berglund PA, Coulouvrat C, Hajak G, Roth T, Shahly V, Shillington AC, Stephenson JJ, Walsh JK (2011) Insomnia and the performance of US workers: results from the America insomnia survey. Sleep Med 34(9):1161–1171. doi:10.5665/SLEEP.1230
Dregan A, Armstrong D (2011) Cross-country variation in sleep disturbance among working and older age groups: an analysis based on the European Social Survey. Int Psychogeriatr 23(9):1413–1420. doi:10.1017/s1041610211000664
Kato T (2013) Insomnia symptoms, depressive symptoms, and suicide ideation in Japanese white-collar employees. Int J Behav Med 21:506–510. doi:10.1007/s12529-013-9364-4
Nakata A, Haratani T, Takahashi M, Kawakami N, Arito H, Kobayashi F, Araki S (2013) Job stress, social support, and prevalence of insomnia in a population of Japanese daytime workers. Soc Sci Med 59:1719–1730. doi:10.1016/j.socscimed.2004.02.002
Ota A, Masue T, Yasuda N, Tsutsumi A, Mino Y, Ohara H, Ono Y (2009) Psychosocial job characteristics and insomnia: a prospective cohort study using the Demand-Control-Support (DCS) and Effort–Reward Imbalance (ERI) job stress models. Sleep Med 10:1112–1117. doi:10.1016/j.sleep.2009.03.005
Gosling JA, Batterham PJ, Glozier N, Christensen H (2014) The influence of job stress, social support and health status on intermittent and chronic sleep disturbance: an 8-year longitudinal analysis. Sleep Med 15:979–985
Sinokki M, Ahola K, Hinkka K, Sallinen M, Härmä M, Puukka P, SC M, Klaukka T, Lönnqvist J, Virtanen M (2010) The association of social support at work and in private life with sleeping problems in the Finnish Health 2000 study. J Occup Environ Med 52(1):54–61. doi:10.1097/JOM.0b013e3181c5c373
Mak Y, Wu C, Hui D, Lam S, Tse H, Yu W, Ho W (2014) Association between screen viewing duration and sleep duration, sleep quality, and excessive daytime sleepiness among adolescents in Hong Kong. Int J Environ Res Public Health 11:11201–11219. doi:10.3390/ijerph111111201
Leger D, Bayon V, Elbaz M, Philip P, Choudat D (2011) Underexposure to light at work and its association to insomnia and sleepiness. J Psychosom Res 70:29–36. doi:10.1016/j.jpsychores.2010.09.006
Swanson LM, Arnedt JT, Rosekind MR, Belenky G, Balkin TJ, Drake C (2008) Sleep disorders and work performance: findings from the 2008 National Sleep Foundation Sleep in America poll. J Sleep Res 20:487–494. doi:10.1111/j.1365-2869.2010.00890.x
Lian Y, Xiao J, Liu Y, Ning L, Guan S, Ge H, Li F, Liu J (2015) Associations between insomnia, sleep duration and poor work ability. J Psychosom Res 78:45–51
Kucharczyk ER, Morgan K, Hall AP (2012) The occupational impact of sleep quality and insomnia symptoms. Sleep Med Rev 16(6):547–559. doi:10.1016/j.smrv.2012.01.005
Shahly V, Berglund PA, Coulouvrat C, Fitzgerald T, Hajak G, Roth T (2012) The associations of insomnia with costly workplace accidents and errors. Arch Gen Psychiatry 69(10):1054–1063
Uehli K, Miedinger D, Bingisser R, Dürr S, Holsboer-Trachsler E, Maier S, Mehta AJ, Müller R, Schindler C, Zogg S, Künzli Leuppi J (2014) Sleep quality and the risk of work injury: a Swiss case–control study. J Sleep Res 23:545–553. doi:10.1111/jsr.12146
Nomura K, Nakao M, Takeuchi T, Yano E (2009) Associations of insomnia with job strain, control, and support among male Japanese workers. Sleep Med 10(6):626–629. doi:10.1016/j.sleep.2008.06.010
Kim HC, Kim BK, Min KB, Min YJ, Hwang SH, Park SG (2011) Association between job stress and insomnia in Korean workers. J Occup Health 53:164–174
Sakurai K, Nakata A, Ikeda T, Otsuka Y, Kawahito J (2013) Employment type, workplace interpersonal conflict, and insomnia: a cross-sectional study of 37,646 employees in Japan. Arch Environ Occup Health 69(1):23–32. doi:10.1080/19338244.2012.713040
Palagini L, Biber K, Riemann D (2014) The genetics of insomnia—evidence for epigenetic mechanisms? Sleep Med Rev 18:225–235
Dauvilliers Y, Maret S, Tafti M (2005) Genetics of normal and pathological sleep in humans. Sleep Med Rev 9:91–100. doi:10.1016/j.smrv.2004.06.001
Drake CL, Friedman NP, Friedman NP, Wright KP, Roth T (2011) Sleep reactivity and insomnia: genetic and environmental influences. Sleep Med 34(9):1179–1188. doi:10.5665/Sleep.1234
Hamet P, Tremblay J (2006) Genetics of the sleep-wake cycle and its disorders. Metabolism 55:S7–S12. doi:10.1016/j.metabol.2006.07.006
Mignot E, Takahashi JS (2007) A circadian sleep disorder reveals a complex clock. Cell 128:22–23. doi:10.1016/j.cell.2006.12.024
Taheri S, Mignot E (2002) The genetics of sleep disorders. Lancet Neurol 1:242–250
Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptáček LJ (2007) Modeling of a human circadian mutation yields novel insights into clock regulation by PER2. Cell 128(1):59–70
Zheng B, Larkin DW, Albrecht U, Sun ZS, Sage M, Eichele G, Lee CC, Bradley A (1999) The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 400:169–173
Kopp C, Albrecht U, Zheng B, Tobler I (2002) Homeostatic sleep regulation is preserved in mPer1 and mPer2 mutant mice. Eur J Neurosci 16:1099–1106. doi:10.1046/j.1460-9568.2002.02156.x
Zheng B, Albretch U, Kaasik K, Sage M, Lu W, Vaishnav S, Li Q, Sun ZS, Eichele G, Bradley A, Lee CC (2001) Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105:683–694
K B, Jin X, Maywood ES, Hastings MH, Reppert SM, Weaver DR (2001) Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30:525–536
Carpen JD, Archer SN, Skene DJ, Smits M, von Schantz M (2005) A single-nucleotide polymorphism in the 5’-untranslated region of the hPER2 gene is associated with diurnal preference. J Sleep Res 14:293–297
Parsons MJ, Lester KJ, Barclay NL, Archer SN, Nolan PM, Eley TC, Gregory A (2014) Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures. J Sleep Res 23:595–604. doi:10.1111/jsr.12144
Toh KL Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptácek LJ, Fu YH (2001) An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. SCIENCE. 1041–1043 -->
Soldators CR, Dikeos DG, Paparrigopoulos TJ (2000) Athens insomnia scale: validation of an instrument based on ICD-10 criteria. J Psychosom Res 48:555–560
Yu SF MQ, Zhou LC, Li ZJ, Gao P, Li WS (1998) Reliability and validity of Chinese version of the NIOSH generic job stress questionnaire. Chinese J Behav Sci 22–24
Huang C, Li J, Lu L, Ren X, Li Y, Huang Q, Lan Y, Wang Y (2014) Interaction between serotonin transporter gene-linked polymorphic region (5-HTTLPR) and job-related stress in insomnia: a cross-sectional study in Sichuan, China. Sleep Med 15:1269–1275
Nishitani N, Sakakibara H (2010) Job stress factors, stress response, and social support in association with insomnia of Japanese male workers. Ind Health 48:178–184
Knudsen HK, Ducharme LJ, Roman PM (2007) Job stress and poor sleep quality: data from an American sample of full-time workers. Soc Sci Med 64(10):1997–2007. doi:10.1016/j.socscimed.2007.02.020
Åkerstedt T, Nordin M, Alfredsson L, Westerholm P, Kecklund G (2012) Predicting changes in sleep complaints from baseline values and changes in work demands, work control, and work preoccupation—the WOLF-project. Sleep Med 13(1):73–80. doi:10.1016/j.sleep.2011.04.015
Kudielka BM, Von Känel R, Gander M-L, Fischer JE (2004) Effort-reward imbalance, overcommitment and sleep in a working population. Work Stress 18(2):167–178. doi:10.1080/02678370410001731785
Rugulies R, Norborg M, Sørensen TS, Knudsen LE, Burr H (2009) Effort–reward imbalance at work and risk of sleep disturbances. Cross-sectional and prospective results from the Danish work environment cohort study. J Psychosom Res 66:75–83. doi:10.1016/j.jpsychores.2008.05.005
Byrne EM, Johnson J, McRae AF, Nyholt DR, Medland SE, Gehrman PR, Heath AC, Madden PAF, Montgomery GW, Georgia CT, Martin NG (2012) A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. Sleep Med 35(7):967–975
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Li, J., Huang, C., Lan, Y. et al. A cross-sectional study on the relationships among the polymorphism of period2 gene, work stress, and insomnia. Sleep Breath 19, 1399–1406 (2015). https://doi.org/10.1007/s11325-015-1229-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11325-015-1229-4