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Renal functions in obstructive sleep apnea patients

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Abstract

Purpose

The aim of this study is to investigate possible factors influencing glomerular filtration rate (GFR) in obstructive sleep apnea (OSA).

Methods

Data of OSA patients admitted to Gaziantep University sleep clinic from January 2005 to January 2010 were retrospectively evaluated. GFR is calculated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Patients younger than 18 years old were excluded.

Results

The mean age of OSA (n = 634) and control group (n = 62) were 51.13 ± 11.61 and 50.69 ± 13.88 years, respectively (p = 0.81). The mean estimated GFR (eGFR) was 90.73 ± 19.59 ml/min/1.73 m2 in OSA patients and 94.14 ± 18.81 ml/min/1.73 m2 in control subjects (p = 0.19). GFR was 84.25 ± 20.87 ml/min/1.73 m2 in patients with left ventricular hypertrophy (LVH) while it was 93.94 ± 18.44 ml/min/1.73 m2 in patients without LVH (p = 0.00). GFR of male subjects was 92.1 ± 19.23 in OSA and 95.84 ± 20.08 ml/min/1.73 m2 in controls (p = 0.33). GFR of female and male patients in the OSA were 87.45 ± 20.10 and 92.91 ± 18.02 ml/min/1.73 m2, respectively (p = 0.13). Serum creatinine was higher in OSA patients compared to controls (p = 0.01). GFR was 92.30 ± 19.27 in male and 88.33 ± 19.84 ml/min/1.73 m2 in female subjects (p = 0.01). GFR was 84.86 ± 19.95 in hypertensive patients while it was 95.11 ± 18.20 ml/min/1.73 m2 in normotensive subjects (p = 0.00). GFR was 89.30 ± 19.96 in patients with metabolic syndrome (MetS) and it was 93.46 ± 18.68 ml/min/1.73 m2 in patients without MetS (p = 0.00).

Conclusions

GFR values were lower in sleep apneic patients with MetS as well as in patients with hypertension and LVH.

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Acknowledgments

We would like to thank to Neriman Aydın, MD, for statistical evaluation of the study.

Conflict of Interest

The authors declare that they have no competing interests.

Author information

Authors and Affiliations

  1. Department of Pulmonary Diseases, Gaziantep University, Gaziantep, 27035, Turkey

    Meral Uyar, Nevhiz Gündoğdu & Deniz Kosovalı

  2. Department of Cardiology, Gaziantep University, Gaziantep, 27035, Turkey

    Vedat Davutoğlu & İbrahim Sarı

Authors
  1. Meral Uyar
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  2. Vedat Davutoğlu
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  3. Nevhiz Gündoğdu
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  4. Deniz Kosovalı
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  5. İbrahim Sarı
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Correspondence to Meral Uyar.

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Uyar, M., Davutoğlu, V., Gündoğdu, N. et al. Renal functions in obstructive sleep apnea patients. Sleep Breath 20, 191–195 (2016). https://doi.org/10.1007/s11325-015-1204-0

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  • DOI: https://doi.org/10.1007/s11325-015-1204-0

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