Sleep and Breathing

, Volume 19, Issue 2, pp 579–583

The effect of vitamin D supplements on the severity of restless legs syndrome

  • Siraj Wali
  • Afnan Shukr
  • Ayah Boudal
  • Ahmad Alsaiari
  • Ayman Krayem
Original Article

DOI: 10.1007/s11325-014-1049-y

Cite this article as:
Wali, S., Shukr, A., Boudal, A. et al. Sleep Breath (2015) 19: 579. doi:10.1007/s11325-014-1049-y

Abstract

Purpose

Clinical observation hinted improved symptoms of restless legs syndrome (RLS) after vitamin D supplements. Hence, the aim of this study is to evaluate the effect of vitamin D supplementation on the severity of RLS symptoms.

Methods

Twelve adult subjects diagnosed with primary RLS and vitamin D deficiency were recruited. Patients with secondary RLS were excluded from this study. The complete cell count; serum levels of ferritin, iron, glycated hemoglobin, and vitamin D3 (25 (OH) vitamin D); and renal and bone profiles of the patients were assayed. Patients with vitamin D deficiency (<50 nmol/l) were treated with vitamin D3 supplements (high oral dose or intramuscular injection). The severity scores of RLS were reassessed after the vitamin D3 level was corrected to >50 nmol/l and compared with those before the administration of the supplements.

Results

The median pretreatment vitamin D level was 21.7 nmol/l (13.45–57.4), which improved to 61.8 nmol/l (42.58–95.9) (P = 0.002) with the treatment. The median RLS severity score improved significantly from 26 (15–35) at baseline to 10 (0–27) after correction of the vitamin D levels (P = 0.002).

Conclusion

This study indicates that vitamin D supplementation improves the severity of RLS symptoms and advocates that vitamin D deficiency is conceivably associated with RLS.

Keywords

Restless legs syndrome Vitamin D deficiency Rating score Diagnosis 

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Siraj Wali
    • 1
    • 3
  • Afnan Shukr
    • 1
  • Ayah Boudal
    • 1
  • Ahmad Alsaiari
    • 1
  • Ayman Krayem
    • 2
  1. 1.Sleep Medicine and Research CenterKing Abdulaziz UniversityJeddahSaudi Arabia
  2. 2.Sleep Disorders CenterKing Abdulaziz Medical CityJeddahSaudi Arabia
  3. 3.Associate Professor of Medicine College of MedicineKing Abdulaziz University Sleep Medicine and Research Center King Abdulaziz University HospitalJeddahSaudi Arabia

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