Sleep and Breathing

, Volume 17, Issue 2, pp 867–871 | Cite as

Antioxidant vitamins prevent oxidative and carbonyl stress in an animal model of obstructive sleep apnea

  • Peter CelecEmail author
  • Ingrid Jurkovičová
  • Roman Buchta
  • Ivan Bartík
  • Roman Gardlík
  • Roland Pálffy
  • Imrich Mucska
  • Július Hodosy
Short Communication



The aim of our study was to analyze the effects of an antioxidant treatment on markers of oxidative and carbonyl stress in a rat model of obstructive sleep apnea.


Wistar rats were randomized into six groups—according to gender and intervention—sham, intermittent hypoxia, and intermittent hypoxia with treatment by vitamins C and E. Rats underwent tracheostomy. The tracheal cannula was closed for 12 s every minute for 1 h to simulate obstructive sleep apnea-related intermittent hypoxia. In the treatment group, rats received vitamin C and E 24 h prior to surgery.


The intervention had a significant effect on advanced oxidation protein products (p = 0.008) and advanced glycation end products–specific fluorescence (p = 0.006) but no effect on malondialdehyde. Oxidation and glycation protein products were higher in intermittent hypoxia groups than in sham and in treated groups.


Antioxidants alleviate oxidative and carbonyl stress in an experimental model of obstructive sleep apnea. Future studies will show whether such treatment has any clinical value regarding cardiovascular complications of sleep apnea syndrome, preferably in patients with low compliance to continuous positive airway pressure.


Sleep apnea Oxidative stress Carbonyl stress Antioxidative therapy AGEs 


Conflicts of interest


Disclosure of financial support

This publication is the result of the project implementation: “TRANSMED 2” ITMS: 26240120030 supported by the Research and Development Operational Program funded by the ERDF.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Peter Celec
    • 1
    • 2
    • 3
    Email author
  • Ingrid Jurkovičová
    • 4
  • Roman Buchta
    • 1
  • Ivan Bartík
    • 1
  • Roman Gardlík
    • 1
  • Roland Pálffy
    • 1
  • Imrich Mucska
    • 4
  • Július Hodosy
    • 1
    • 4
    • 5
  1. 1.Institute of Molecular BiomedicineComenius UniversityBratislavaSlovak Republic
  2. 2.Institute of PathophysiologyComenius UniversityBratislavaSlovakia
  3. 3.Department of Molecular BiologyComenius UniversityBratislavaSlovakia
  4. 4.University HospitalBratislavaSlovakia
  5. 5.Institute of PhysiologyComenius UniversityBratislavaSlovakia

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