Antioxidant vitamins prevent oxidative and carbonyl stress in an animal model of obstructive sleep apnea
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The aim of our study was to analyze the effects of an antioxidant treatment on markers of oxidative and carbonyl stress in a rat model of obstructive sleep apnea.
Wistar rats were randomized into six groups—according to gender and intervention—sham, intermittent hypoxia, and intermittent hypoxia with treatment by vitamins C and E. Rats underwent tracheostomy. The tracheal cannula was closed for 12 s every minute for 1 h to simulate obstructive sleep apnea-related intermittent hypoxia. In the treatment group, rats received vitamin C and E 24 h prior to surgery.
The intervention had a significant effect on advanced oxidation protein products (p = 0.008) and advanced glycation end products–specific fluorescence (p = 0.006) but no effect on malondialdehyde. Oxidation and glycation protein products were higher in intermittent hypoxia groups than in sham and in treated groups.
Antioxidants alleviate oxidative and carbonyl stress in an experimental model of obstructive sleep apnea. Future studies will show whether such treatment has any clinical value regarding cardiovascular complications of sleep apnea syndrome, preferably in patients with low compliance to continuous positive airway pressure.
KeywordsSleep apnea Oxidative stress Carbonyl stress Antioxidative therapy AGEs
Conflicts of interest
Disclosure of financial support
This publication is the result of the project implementation: “TRANSMED 2” ITMS: 26240120030 supported by the Research and Development Operational Program funded by the ERDF.
- 9.Cui L, Wang JH, Wang M, Huang M, Wang CY, Xia H, Xu JG, Li MX, Wang S (2011) Injection of l-glutamate into the insular cortex produces sleep apnea and serotonin reduction in rats. Sleep Breath. doi: 10.1007/s11325-011-0586-x
- 14.Katalinic V, Modun D, Music I, Boban M (2005) Gender differences in antioxidant capacity of rat tissues determined by 2,2'-azinobis (3-ethylbenzothiazoline 6-sulfonate; ABTS) and ferric reducing antioxidant power (FRAP) assays. Comp Biochem Physiol C Toxicol Pharmacol 140:47–52PubMedCrossRefGoogle Scholar
- 21.Celec P, Jani P, Smrekova L, Mrlian A, Kudela M, Hodosy JD, Boor P, Kristova V, Jakubovsky J, Jezova D, Halcak L, Bozek P, Slamova J, Ulicna O, Hojsik D, Jurkovicova I (2003) Effects of anabolic steroids and antioxidant vitamins on ethanol-induced tissue injury. Life Sci 74:419–434PubMedCrossRefGoogle Scholar
- 22.Yokoe T, Minoguchi K, Matsuo H, Oda N, Minoguchi H, Yoshino G, Hirano T, Adachi M (2003) Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure. Circulation 107:1129–1134PubMedCrossRefGoogle Scholar