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Changes in cerebral hemoglobin indices in obstructive sleep apnea syndrome with nasal continuous positive airway pressure treatment

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Abstract

Introduction

This study examined both the relationship between the changes in the brain tissue hemoglobin indices and SpO2 during sleep in patients with obstructive sleep apnea syndrome (OSAS) and the effect of nasal continuous positive airway pressure (CPAP) treatment on hemoglobin indices.

Materials and methods

Polysomnographic recordings and near-infrared spectroscopy (NIRS) were performed during an afternoon nap on 15 OSAS patients before treatment and 12 healthy controls. Oxyhemoglobin (HbO), deoxyhemoglobin (HbD), and total hemoglobin (HbT) on NIRS were analyzed, and the correlation of these variables and peripheral arterial oxygen saturation (SpO2) were investigated in the OSAS group before nasal CPAP treatment. In nine OSAS patients, the recordings were also compared between the condition with and without using CPAP.

Results

HbO decreased during obstructive respiratory events while HbT and HbD showed adverse increases, and the values of these hemoglobin indices returned to the baseline values at the end of each respiratory event in the OSAS group. The fluctuations in these cerebral hemoglobin indices during sleep were significantly larger in the OSAS group than in the control group. Moreover, in the OSAS group, these changes correlated strongly with the change in SpO2. When using CPAP, not only respiratory events but also the fluctuations in both the cerebral hemoglobin indices and SpO2 were almost completely suppressed.

Conclusion

Arterial oxygen desaturation is clearly related to cerebral oxygenation, and fluctuations of hemoglobin indices can be suppressed with CPAP.

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Acknowledgment

The authors are indebted to Prof. J. Patrick Barron of the Department of International Medical Communications of Tokyo Medical University for his review of this manuscript.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan

    Akira Matsuo & Hiroshige Chiba

  2. Department of Somnology, Tokyo Medical University, 6-7-1 Nishishinjuku, 160-0023, Shinjuku-ku, Tokyo, Japan

    Yuichi Inoue

  3. Japan Somnology Center, Neuropsychiatric Research Institute, 1-17-7-301 Yoyogi, 151-0053, Shibuya-Ku, Tokyo, Japan

    Yuichi Inoue & Kazuyoshi Namba

Authors
  1. Akira Matsuo
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  2. Yuichi Inoue
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  3. Kazuyoshi Namba
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  4. Hiroshige Chiba
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Corresponding authors

Correspondence to Akira Matsuo or Yuichi Inoue.

Additional information

Yuichi Inoue and Akira Matsuo contributed equally to this case report.

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Matsuo, A., Inoue, Y., Namba, K. et al. Changes in cerebral hemoglobin indices in obstructive sleep apnea syndrome with nasal continuous positive airway pressure treatment. Sleep Breath 15, 487–492 (2011). https://doi.org/10.1007/s11325-010-0367-y

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  • DOI: https://doi.org/10.1007/s11325-010-0367-y

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