Sleep and Breathing

, Volume 11, Issue 4, pp 239–244 | Cite as

Effect of a 2 week CPAP treatment on mood states in patients with obstructive sleep apnea: a double-blind trial

  • Alexander HaenselEmail author
  • Daniel Norman
  • Loki Natarajan
  • Wayne A. Bardwell
  • Sonia Ancoli-Israel
  • Joel E. Dimsdale
Original Article


Obstructive sleep apnea (OSA) is a common disease with significant medical and psychiatric comorbidities. The literature documenting the effects of continuous positive airway pressure (CPAP) treatment on mood in OSA patients is mixed. We previously observed that 1 week of CPAP treatment did not result in improvements in mood beyond those observed in a group treated with placebo–CPAP. This study examined the effect of a 2 week CPAP treatment on mood in a placebo-controlled design in OSA patients. Fifty patients with untreated sleep apnea were evaluated by polysomnography and completed the Profile of Mood States (POMS) pre-/post-treatment. The patients were randomized for 2 weeks to either therapeutic CPAP or placebo–CPAP (at insufficient pressure). Both the therapeutic CPAP and the placebo–CPAP groups showed significant improvements in POMS total score, tension, fatigue, and confusion. No significant time × treatment effect was observed for either group. We could not show a specific beneficial impact of CPAP treatment on mood in OSA patients.


Obstructive sleep apnea Mood disorders Continuous positive airway pressure POMS 



This research was supported by NIH grants AG08415, HL44915, HL36005, and RR00827.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Alexander Haensel
    • 1
    • 2
    • 5
    Email author
  • Daniel Norman
    • 4
  • Loki Natarajan
    • 3
  • Wayne A. Bardwell
    • 2
    • 3
  • Sonia Ancoli-Israel
    • 2
    • 3
  • Joel E. Dimsdale
    • 2
    • 3
  1. 1.Department of General Internal MedicineUniversity Hospital BerneBernSwitzerland
  2. 2.Department of PsychiatryUniversity of CaliforniaSan DiegoUSA
  3. 3.Moores UCSD Cancer CenterLa JollaUSA
  4. 4.Pulmonary and Critical Care MedicineUniversity of CaliforniaSan DiegoUSA
  5. 5.USCD PsychiatryLa JollaUSA

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