Retrospective Brain Motion Correction in Glutamate Chemical Exchange Saturation Transfer (GluCEST) MRI

  • Dong-Hoon Lee
  • Do-Wan Lee
  • Jae-Im Kwon
  • Chul-Woong Woo
  • Sang-Tae Kim
  • Jeong Kon Kim
  • Kyung Won Kim
  • Dong-Cheol WooEmail author
Research Article



To evaluate the feasibility of motion correction in glutamate chemical exchange saturation transfer (GluCEST) imaging, using a rat model of epileptic seizure.


Epileptic seizure was induced in six male Wistar rats by intraperitoneal injection of kainic acid (KA). CEST data were obtained using a 7.0 T Bruker MRI scanner before and 3 h after KA injection. Retrospective motion correction was performed in CEST images using a gradient-based motion correction (GradMC) algorithm. GluCEST signals in the hippocampal regions were quantitatively evaluated with and without motion correction.


Calculated GluCEST signals differed significantly between the pre-KA injection group, regardless of motion-correction implementation, and the post-KA injection group with motion correction (3.662 ± 1.393 % / 3.726 ± 1.982 % for pre-KA injection group with/without motion correction vs. 6.996 ± 1.684 % for post-KA injection group with motion correction; all P < 0.05).


Our results clearly show that GradMC can be used in CEST imaging for efficient correction of seizure-like motion. The GradMC can be further implemented in various CEST imaging techniques to increase the accuracy of analysis.


Chemical exchange saturation transfer Gradient-based motion correction Glutamate Retrospective motion correction 


Funding Information

This study was supported by grants from the Basic Science Research Program, through the National Research Foundation of Korea (NRF-2017R1A6A3A03012461, NRF-2018R1A2B2007694, and NRF-2018R1C1B6004521), and the Korea Health Technology R&D Project, through the Korea Health Industry Development Institute (HI14C1090), funded by the Ministry of Health and Welfare, Republic of Korea. This study was also supported by the 2017 University of Sydney Postdoctoral Fellowship Scheme (192237).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© World Molecular Imaging Society 2019

Authors and Affiliations

  1. 1.Faculty of Health Sciences and Brain and Mind CentreThe University of SydneySydneyAustralia
  2. 2.Center for Bioimaging of New Drug Development, Asan Medical CenterAsan Institute for Life SciencesSeoulRepublic of Korea
  3. 3.MR Core Laboratory, Convergence Medicine Research Center, Asan Medical CenterAsan Institute for Life SciencesSeoulRepublic of Korea
  4. 4.Department of Radiology, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea
  5. 5.Department of Convergence Medicine, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea

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