Molecular Imaging and Biology

, Volume 20, Issue 2, pp 318–323 | Cite as

Histogram Analysis of T1-Weighted, T2-Weighted, and Postcontrast T1-Weighted Images in Primary CNS Lymphoma: Correlations with Histopathological Findings—a Preliminary Study

  • Hans-Jonas Meyer
  • Stefan Schob
  • Benno Münch
  • Clara Frydrychowicz
  • Nikita Garnov
  • Ulf Quäschling
  • Karl-Titus Hoffmann
  • Alexey Surov
Research Article

Abstract

Purpose

Previously, some reports mentioned that magnetic resonance imaging (MRI) can predict histopathological features in primary CNS lymphoma (PCNSL). The reported data analyzed diffusion-weighted imaging findings. The aim of this study was to investigate possible associations between histopathological findings, such as tumor cellularity, nucleic areas and proliferation index Ki-67, and signal intensity on T1-weighted and T2-weighted images in PCNSL.

Procedures

For this study, 18 patients with PCNSL were retrospectively investigated by histogram analysis on precontrast and postcontrast T1-weighted and fluid-attenuated inversion recovery (FLAIR) images. For every patient, histopathology parameters, nucleic count, total nucleic area, and average nucleic area, as well as Ki-67 index, were estimated.

Results

Correlation analysis identified several statistically significant associations. Skewness derived from precontrast T1-weighted images correlated with Ki-67 index (p = − 0.55, P = 0.028). Furthermore, entropy derived from precontrast T1-weighted images correlated with average nucleic area (p = 0.53, P = 0.04). Several parameters from postcontrast T1-weighted images correlated with nucleic count: maximum signal intensity (p = 0.59, P = 0.017), P75 (p = 0.56, P = 0.02), and P90 (p = 0.52, P = 0.04) as well as SD (p = 0.58, P = 0.02). Maximum signal intensity derived from FLAIR sequence correlated with nucleic count (p = 0.50, P = 0.03).

Conclusion

Histogram-derived parameters of conventional MRI sequences can reflect different histopathological features in PSNCL.

Key words

Primary CNS lymphoma Signal intensity T1-weighted images T2-weighted images Signal intensity Histopathology Ki-67 

Abbreviations

ADC

Apparent diffusion coefficient

DCE

Dynamic contrast-enhanced MRI

DWI

Diffusion-weighted imaging

PCNSL

Primary CNS lymphoma

ROI

Region of interest

SI

Signal intensity

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© World Molecular Imaging Society 2017

Authors and Affiliations

  1. 1.Department of Diagnostic and Interventional RadiologyUniversity Hospital LeipzigLeipzigGermany
  2. 2.Department of NeuroradiologyUniversity Hospital LeipzigLeipzigGermany
  3. 3.Department of NeuropathologyUniversity Hospital LeipzigLeipzigGermany

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