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Seeing SPIOs Directly In Vivo with Magnetic Particle Imaging

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Abstract

Magnetic particle imaging (MPI) is a new molecular imaging technique that directly images superparamagnetic tracers with high image contrast and sensitivity approaching nuclear medicine techniques—but without ionizing radiation. Since its inception, the MPI research field has quickly progressed in imaging theory, hardware, tracer design, and biomedical applications. Here, we describe the history and field of MPI, outline pressing challenges to MPI technology and clinical translation, highlight unique applications in MPI, and describe the role of the WMIS MPI Interest Group in collaboratively advancing MPI as a molecular imaging technique. We invite interested investigators to join the MPI Interest Group and contribute new insights and innovations to the MPI field.

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Acknowledgments

We are grateful for funding support from the Keck Foundation Grant 009323, NIH 1R01EB019458, NIH 1R24MH106053, and a UC Discovery Grant.

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Authors and Affiliations

  1. Department of Bioengineering, UC Berkeley, Berkeley, CA, USA

    Bo Zheng, Elaine Yu, Ryan Orendorff, Zhi Wei Tay, Daniel Hensley, Xinyi Y Zhou, Prashant Chandrasekharan & Steven M Conolly

  2. Triple Ring Technologies, Newark, CA, USA

    Kuan Lu

  3. Magnetic Insight, Alameda, CA, USA

    Justin J Konkle, Daniel Hensley & Patrick W Goodwill

  4. Department of Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey

    Emine U Saritas

  5. National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey

    Emine U Saritas

  6. Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    John D Hazle

  7. Department of Electrical Engineering and Computer Science, UC Berkeley, Berkeley, CA, USA

    Steven M Conolly

Authors
  1. Bo Zheng
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  2. Elaine Yu
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  5. Justin J Konkle
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  10. Emine U Saritas
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  11. Patrick W Goodwill
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  13. Steven M Conolly
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Corresponding author

Correspondence to Bo Zheng.

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Conflict of Interest

PWG and SMC are founders of Magnetic Insight. PWG, DWH, and JJK are employees of Magnetic Insight.

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Zheng, B., Yu, E., Orendorff, R. et al. Seeing SPIOs Directly In Vivo with Magnetic Particle Imaging. Mol Imaging Biol 19, 385–390 (2017). https://doi.org/10.1007/s11307-017-1081-y

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  • DOI: https://doi.org/10.1007/s11307-017-1081-y

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