Molecular Imaging and Biology

, Volume 19, Issue 5, pp 645–655 | Cite as

Fluorescence Imaging for Cancer Screening and Surveillance

  • K. E. Tipirneni
  • E. L. Rosenthal
  • L. S. Moore
  • A. D. Haskins
  • N. Udayakumar
  • A. H. Jani
  • W. R. Carroll
  • A. B. Morlandt
  • M. Bogyo
  • J. Rao
  • Jason M. WarramEmail author
Review Article


The advent of fluorescence imaging (FI) for cancer cell detection in the field of oncology is promising for both cancer screening and surgical resection. Particularly, FI in cancer screening and surveillance is actively being evaluated in many new clinical trials with over 30 listed on Clinical While surgical resection forms the foundation of many oncologic treatments, early detection is the cornerstone for improving outcomes and reducing cancer-related morbidity and mortality. The applications of FI are twofold as it can be applied to high-risk patients in addition to those undergoing active surveillance. This technology has the promise of highlighting lesions not readily detected by conventional imaging or physical examination, allowing disease detection at an earlier stage of development. Additionally, there is a persistent need for innovative, cost-effective imaging modalities to ameliorate healthcare disparities and the global burden of cancer worldwide. In this review, we outline the current utility of FI for screening and detection in a range of cancer types.

Key words

Cancer screening Early detection of cancer Neoplasms Diagnostic imaging Optical imaging Molecular imaging 



We have no acknowledgements and there is no funding involved with the preparation of this manuscript.

Compliance with Ethical Standards

Conflict of Interests

The authors declare that they have no conflict of interest.

Funding Sources

This work was supported by the National Institutes of Health (T32CA091078).


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Copyright information

© World Molecular Imaging Society 2017

Authors and Affiliations

  • K. E. Tipirneni
    • 1
  • E. L. Rosenthal
    • 2
  • L. S. Moore
    • 3
  • A. D. Haskins
    • 3
  • N. Udayakumar
    • 4
  • A. H. Jani
    • 5
  • W. R. Carroll
    • 3
  • A. B. Morlandt
    • 6
  • M. Bogyo
    • 7
  • J. Rao
    • 8
  • Jason M. Warram
    • 3
    • 9
    Email author
  1. 1.Department of SurgeryUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Department of OtolaryngologyStanford UniversityStanfordUSA
  3. 3.Department of OtolaryngologyUniversity of Alabama at BirminghamBirminghamUSA
  4. 4.Department of BiologyUniversity of Alabama at BirminghamBirminghamUSA
  5. 5.School of MedicineUniversity of Alabama at BirminghamBirminghamUSA
  6. 6.Department of Oral and Maxillofacial SurgeryUniversity of Alabama at BirminghamBirminghamUSA
  7. 7.Department of PathologyStanford UniversityStanfordUSA
  8. 8.Department of RadiologyStanford UniversityStanfordUSA
  9. 9.Departments of Otolaryngology, Neurosurgery, & RadiologyThe University of Alabama at BirminghamBirminghamUSA

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