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Standardized Uptake Value in High Uptake Area on Positron Emission Tomography with 18F-FRP170 as a Hypoxic Cell Tracer Correlates with Intratumoral Oxygen Pressure in Glioblastoma

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Abstract

Purpose

The aim of this study was to clarify the reliability of positron emission tomography (PET) using a new hypoxic cell tracer, 1-(2-[18F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole (18F-FRP170).

Procedures

Twelve patients with glioblastoma underwent 18F-FRP170 PET before tumor resection. Mean standardized uptake value (SUV) and normalized SUV were calculated at regions within a tumor showing high (high-uptake area) and relatively low (low-uptake area) accumulations of 18F-FRP170. In these areas, intratumoral oxygen pressure (tpO2) was measured using microelectrodes during tumor resection.

Results

Mean tpO2 was significantly lower in the high-uptake area than in the low-uptake area. A significant negative correlation was evident between normalized SUV and tpO2 in the high-uptake area.

Conclusion

The present findings suggest that high accumulation on 18F-FRP170 PET represents viable hypoxic tissues in glioblastoma.

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Abbreviations

Cu-ATSM:

64Cu-diacetyl-bis(N4-methylthiosemicarbazone)

18F-FRP170:

1-(2-[18F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole

18F-FAZA:

1-α-d-(5-deoxy-5-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole

18F-FMISO:

[18F]fluoromisonidazole

Gd-T1WI:

Gadolinium-enhanced T1-weighted imaging

HIF:

Hypoxic-inducible factor

MRI:

Magnetic resonance imaging

ROI:

Region of interest

T2WI:

T2-weighted imaging

PET:

Positron emission tomography

VEGF:

Vascular endothelial growth factor

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Acknowledgments

This study was supported in part by Grant-in-Aid for Strategic Medical Science Research Center for Advanced Medical Science Research from the Ministry of Science, Education, Sports and Culture, Japan.

Conflict of Interest

The authors declare that they have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Iwate Medical University, Uchimaru 19-1, Morioka, 020-8505, Japan

    Takaaki Beppu, Shunrou Fujiwara, Hideki Matsuura & Kuniaki Ogasawara

  2. Cyclotron Research Center, Iwate Medical University, Morioka, Japan

    Kazunori Terasaki, Toshiaki Sasaki & Koichiro Sera

  3. Department of Clinical Pathology, Iwate Medical University, Morioka, Japan

    Noriyuki Yamada, Noriyuki Uesugi & Tamotsu Sugai

  4. Institute for Biomedical Sciences, Iwate Medical University, Morioka, Japan

    Kohsuke Kudo & Makoto Sasaki

  5. Department of Radiology, Iwate Medical University, Morioka, Japan

    Shigeru Ehara

  6. Cyclotron and Radioisotope Center (CYRIC), Tohoku University, Sendai, Japan

    Ren Iwata

  7. Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

    Yoshihiro Takai

Authors
  1. Takaaki Beppu
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  2. Kazunori Terasaki
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  11. Kohsuke Kudo
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  12. Makoto Sasaki
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  13. Shigeru Ehara
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  14. Ren Iwata
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  15. Yoshihiro Takai
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Correspondence to Takaaki Beppu.

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Beppu, T., Terasaki, K., Sasaki, T. et al. Standardized Uptake Value in High Uptake Area on Positron Emission Tomography with 18F-FRP170 as a Hypoxic Cell Tracer Correlates with Intratumoral Oxygen Pressure in Glioblastoma. Mol Imaging Biol 16, 127–135 (2014). https://doi.org/10.1007/s11307-013-0670-7

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  • DOI: https://doi.org/10.1007/s11307-013-0670-7

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