Molecular Imaging and Biology

, Volume 15, Issue 3, pp 299–306 | Cite as

Functionalized Magnetonanoparticles in Visualization of Intracranial Tumors on MRI

  • Massoud Akhtari
  • Whitney Pope
  • Gary Mathern
  • Rex Moats
  • Andrew Frew
  • Mark Mandelkern
Research Article

Abstract

Purpose

The development of nonradioactive and targeted magnetonanoparticles (MNP) capable of crossing the blood–brain barrier (BBB) and of concentrating in and enhancing the contrast of intracranial tumors on magnetic resonance imaging (MRI).

Procedure

Nonradioactive 2-deoxy-d-glucose (2DG) was covalently attached to magnetonanoparticles composed of iron oxide and dextran and prepared for intravenous (tail) injection in the naïve rats and mouse models of glioma. MR images were acquired at 3 and 7 T.

Results

2DG-MNP increased tumor visibility and improved delineation of tumor margins. Histopathology confirmed that 2DG-MNP crossed the BBB and accumulated within brain parenchyma.

Conclusion

Nonradioactive 2DG-MNP can cross an intact BBB on and improve visualization of tumor and tumor margins on MRI.

Key words

Magnetonanoparticles Targeted Glioma 2-Deoxyglucose MRI Contrast 

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Copyright information

© World Molecular Imaging Society 2012

Authors and Affiliations

  • Massoud Akhtari
    • 1
  • Whitney Pope
    • 5
  • Gary Mathern
    • 2
  • Rex Moats
    • 3
  • Andrew Frew
    • 2
  • Mark Mandelkern
    • 4
  1. 1.Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen school of MedicineUniversity of CaliforniaLos AngelesUSA
  2. 2.Department of Neurosurgery, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  3. 3.Department of Radiology, Children’s Hospital of Los AngelesUniversity of Southern CaliforniaLos AngelesUSA
  4. 4.Department of PhysicsUniversity of CaliforniaIrvineUSA
  5. 5.Department of Radiology, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA

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