Abstract
Purpose
The aim of this work was to non-invasively establish the feasibility of assessing 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) lung metabolism with the use of a late dynamic positron emission tomograpy (PET) acquisition, i.e., beyond 2 h after injection.
Procedures
The present method has been probed in 11 patients without any respiratory disease, under fasting conditions, by assessing mean values of 18F-FDG lung metabolism. A kinetic model analysis has been implemented on a simple calculation sheet. An arbitrary (population based) input function has been used in each individual, which was obtained from literature data.
Results
In the healthy lung, no 18F-FDG release was found, and the mean values (±SD) of the 18F-FDG uptake rate constant and of the fraction of the free tracer in blood and interstitial volume were: K = 0.0016 min−1 (±0.0005), and F = 0.18 (±0.10), respectively. These results were in very close agreement with literature data that were obtained by both three-compartment model analysis and Patlak graphical analysis (gold standards), and that used an invasive blood sampling. Furthermore, K and the standard uptake value index have been compared.
Conclusion
We conclude that assessing lung metabolism of 18F-FDG in humans with the use of late dynamic PET imaging is feasible. The arbitrary input function of this non-invasive feasibility study could be replaced in further experiments by an input function obtained by arterial sampling. It is suggested that this method may prove useful to quantify 18F-FDG lung metabolism under pathological conditions.
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Laffon, E., de Clermont, H., Vernejoux, JM. et al. Feasibility of Assessing [18F]FDG Lung Metabolism with Late Dynamic PET Imaging. Mol Imaging Biol 13, 378–384 (2011). https://doi.org/10.1007/s11307-010-0345-6
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DOI: https://doi.org/10.1007/s11307-010-0345-6