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Impact of Nonhybrid 99mTc-MDP-SPECT/CT Image Fusion in Diagnostic and Treatment of Oromaxillofacial Malignancies

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Abstract

Purpose

The aim of this study was to prospectively investigate the clinical impact of image fusion of computed tomography (CT) and single photon emission computed tomography (SPECT) diagnostics in head and neck cancer adjacent or fixed to bony maxillofacial structures.

Procedures

Computer-based manual image fusion has been applied in 74 patients with suspected malignancies in the oromaxillofacial region following CT and SPECT. Afterward, image fusion was compared to separate evaluation of CT and SPECT and visual coregistration with histopathological results serving as control.

Results

In nine out of 74 patients, image fusion achieved more precise anatomical findings regarding tumor dimension than simultaneous evaluation of CT and SPECT, but there was no improvement of identification of bone infiltration.

Conclusion

Manual image fusion of CT and SPECT does not improve identification of bone infiltration compared to simultaneous evaluation. Though particularly in complex anatomical regions, a fixed preoperative diagnostic algorithm in image registration lead to a more precise evaluation and treatment of head and neck malignancies.

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Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Technische Universität München, Ismaninger Str.22, 81675, München, Germany

    Denys John Loeffelbein, Marco Rainer Kesting, Frank Hölzle, Thomas Mücke, Steffen Müller & Klaus-Dietrich Wolff

  2. Department of Radiology and Nuclear Medicine, Ruhr-University Bochum, Bochum, Germany

    Eckhart Mielke

  3. Department of Nuclear Medicine, Technische Universität München, München, Germany

    Andreas Konrad Buck

Authors
  1. Denys John Loeffelbein
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  2. Eckhart Mielke
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  3. Andreas Konrad Buck
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  4. Marco Rainer Kesting
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  5. Frank Hölzle
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  6. Thomas Mücke
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  8. Klaus-Dietrich Wolff
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Correspondence to Denys John Loeffelbein.

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Loeffelbein, D.J., Mielke, E., Buck, A.K. et al. Impact of Nonhybrid 99mTc-MDP-SPECT/CT Image Fusion in Diagnostic and Treatment of Oromaxillofacial Malignancies. Mol Imaging Biol 12, 71–77 (2010). https://doi.org/10.1007/s11307-009-0231-2

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  • DOI: https://doi.org/10.1007/s11307-009-0231-2

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