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Metabolomics as a valid analytical technique in environmental exposure research: application and progress

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Abstract

Background

In recent years, studies have shown that exposure to environmental pollutants (e.g., radiation, heavy metal substances, air pollutants, organic pollutants) is a leading cause of human non-communicable diseases. The key to disease prevention is to clarify the harmful mechanisms and toxic effects of environmental pollutants on the body. Metabolomics is a high-sensitivity, high-throughput omics technology that can obtain detailed metabolite information of an organism. It is a crucial tool for gaining a comprehensive understanding of the pathway network regulation mechanism of the organism. Its application is widespread in many research fields such as environmental exposure assessment, medicine, systems biology, and biomarker discovery.

Aim of review

Recent findings show that metabolomics can be used to obtain molecular snapshots of organisms after environmental exposure, to help understand the interaction between environmental exposure and organisms, and to identify potential biomarkers and biological mechanisms.

Key scientific concepts of review

This review focuses on the application of metabolomics to understand the biological effects of radiation, heavy metals, air pollution, and persistent organic pollutants exposure, and examines some potential biomarkers and toxicity mechanisms.

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Data availability

The data and materials in this article are online and publicly available without request.

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Funding

This work was supported by Key Scientific Research Project of Hunan Health Commission (No.202102051816), Hunan Natural Science Foundation (2019JJ40238) and (2019JJ50509), Hunan Health Commission (C2019096), Hunan Provincial Department of Education (10C0479), the project of Hengyang Science and Technology Bureau (2020jh042).

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Authors and Affiliations

  1. Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province, The Hengyang Key Laboratory of Cellular Stress Biology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Department of Education, Institute of Cytology and Genetics, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China

    Shuang Wei, Yuanyun Wei, Yaqi Gong, Yonglin Chen, Yueqiu Yu, Xiang Lin, Guoqing Li & Lan Yi

  2. Hengyang Medical School, The First Affiliated Hospital, University of South China, Hengyang, 421001, Hunan, China

    Jian Cui

  3. Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang, 421001, Hunan, China

    Linwei Li & Hongxia Yan

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  1. Shuang Wei
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  11. Lan Yi
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Contributions

SW and YW contributed equally to the writing of this article and were major contributors in draft manuscripts. YG, YC, JC, LL, HY, YY, XL, and GL were involved in literature search. LY was involved in conception and instruction of the study and critically revised this manuscript.

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Correspondence to Lan Yi.

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Wei, S., Wei, Y., Gong, Y. et al. Metabolomics as a valid analytical technique in environmental exposure research: application and progress. Metabolomics 18, 35 (2022). https://doi.org/10.1007/s11306-022-01895-7

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