, 14:45 | Cite as

A systematic review of metabolomics biomarkers for Bisphenol A exposure

  • Mu Wang
  • Ouyan Rang
  • Fang Liu
  • Wei Xia
  • Yuanyuan Li
  • Yu Zhang
  • Songfeng Lu
  • Shunqing Xu
Review Article



Bisphenol A (BPA), 2,2-bis(4-hydroxyphenyl) propane, a common industrial chemical which has extremely huge production worldwide, is ubiquitous in the environment. Human have high risk of exposing to BPA and the health problems caused by BPA exposure have aroused public concern. However, the biomarkers for BPA exposure are lacking. As a rapidly developing subject, metabolomics has accumulated a large amount of valuable data in various fields. The secondary application of published metabolomics data could be a very promising field for generating novel biomarkers whilst further understanding of toxicity mechanisms.


To summarize the published literature on the use of metabolomics as a tool to study BPA exposure and provide a systematic perspectives of current research on biomarkers screening of BPA exposure.


We conducted a systematic search of MEDLINE (PubMed) up to the end of June 25, 2017 with the key term combinations of ‘metabolomics’, ‘metabonomics’, ‘mass spectrometry’, ‘nuclear magnetic spectroscopy’, ‘metabolic profiling’ and ‘amino acid profile’ combined with ‘BPA exposure’. Additional articles were identified through searching the reference lists from included studies.


This systematic review included 15 articles. Intermediates of glycolysis, Krebs cycle, β oxidation of long chain fatty acids, pentose phosphate pathway, nucleoside metabolism, branched chain amino acid metabolism, aromatic amino acids metabolism, sulfur-containing amino acids metabolism were significantly changed after BPA exposure, suggesting BPA had a highly complex toxic effects on organism which was consistent with existing studies. The biomarkers most consistently associated with BPA exposure were lactate and choline.


Existing metabolomics studies of BPA exposure present heterogeneous findings regarding metabolite profile characteristics. We need more evidence from target metabolomics and epidemiological studies to further examine the reliability of these biomarkers which link to low, environmentally relevant, exposure of BPA in human body.


BPA Metabolomics Biomarkers Environmental exposure Review 



This work was supported by the Applied Basic Research Program of Wuhan Science and Technology Bureau (2016010101010003); and the independent innovation research fund, HUST (2017KFYXJJ069).

Compliance with ethical standards

Conflict of interest

All the authors declare no conflict of interest.

Ethical approval

This review was conducted in accordance with ethical standards.

Supplementary material

11306_2018_1342_MOESM1_ESM.docx (15 kb)
Supplementary material 1 (DOCX 15 KB)


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhanPeople’s Republic of China
  2. 2.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanPeople’s Republic of China
  3. 3.School of Public HealthUniversity of South ChinaHengyangPeople’s Republic of China
  4. 4.School of Computer and Information TechnologyXinyang Normal UniversityXinyangPeople’s Republic of China

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