Data availability
Data sharing is not applicable as in this case no datasets were generated or analyzed in the generation of this article.
References
Buchanan KL, Rupprecht LE, Kaelberer MM et al (2022) The preference for sugar over sweetener depends on a gut sensor cell. Nat Neurosci 25:191–200. https://doi.org/10.1038/s41593-021-00982-7
Chandrashekar J, Hoon MA, Ryba NJP, Zuker CS (2006) The receptors and cells for mammalian taste. Nature 444:288–294. https://doi.org/10.1038/nature05401
von Molitor E, Riedel K, Krohn M et al (2021) Sweet taste is complex: signaling cascades and circuits involved in sweet sensation. Front Hum Neurosci 15:667709. https://doi.org/10.3389/fnhum.2021.667709
Finger TE, Danilova V, Barrows J et al (2005) ATP signaling is crucial for communication from taste buds to gustatory nerves. Science 310:1495–1499. https://doi.org/10.1126/science.1118435
Damak S, Rong M, Yasumatsu K et al (2003) Detection of sweet and umami taste in the absence of taste receptor T1r3. Science 301:850–853. https://doi.org/10.1126/science.1087155
Ren X, Ferreira JG, Zhou L et al (2010) Nutrient selection in the absence of taste receptor signaling. J Neurosci 30:8012–8023. https://doi.org/10.1523/jneurosci.5749-09.2010
Kaelberer MM, Buchanan KL, Klein ME et al (2018) A gut-brain neural circuit for nutrient sensory transduction. Science 361:eaat5236. https://doi.org/10.1126/science.aat5236
Tan H-E, Sisti AC, Jin H et al (2020) The gut–brain axis mediates sugar preference. Nature 580:511–516. https://doi.org/10.1038/s41586-020-2199-7
Hibberd TJ, Feng J, Luo J et al (2018) optogenetic induction of colonic motility in mice. Gastroenterology 155:514-528.e6. https://doi.org/10.1053/j.gastro.2018.05.029
Schiller M, Azulay-Debby H, Boshnak N et al (2021) Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation. Immunity 54:1022-1036.e8. https://doi.org/10.1016/j.immuni.2021.04.007
Funding
BDG was supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health through R01DK120862 and R01DK103723.
Author information
Authors and Affiliations
Contributions
J.G. wrote the main manuscript text. All authors reviewed the manuscript.
Corresponding author
Ethics declarations
Ethical approval
This article does not contain any studies with human participants or animals performed by the author.
Conflict of interest
The author declares no competing interests.
Additional information
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Gonzales, J., Gulbransen, B.D. Purines help determine the gut’s sweet tooth. Purinergic Signalling 18, 245–247 (2022). https://doi.org/10.1007/s11302-022-09871-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11302-022-09871-5