Skip to main content
SpringerLink
Log in

Inhibiting the P2Y13 receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma

  • Journal Club
  • Published:
Purinergic Signalling Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Lambrecht BN, Hammad H, Fahy JV (2019) The cytokines of asthma. Immunity 50(4):975–991

    Article  CAS  Google Scholar 

  2. Shim EJ, Chun E, Lee HS, Bang BR, Kim TW, Cho SH et al (2012) The role of high-mobility group box-1 (HMGB1) in the pathogenesis of asthma. Clin Exp Allergy 42(6):958–965

    Article  CAS  Google Scholar 

  3. Kondo Y, Yoshimoto T, Yasuda K, Futatsugi-Yumikura S, Morimoto M, Hayashi N et al (2008) Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int Immunol 20(6):791–800

    Article  CAS  Google Scholar 

  4. Werder RB, Ullah MA, Rahman MM, Simpson J, Lynch JP, Collinson N et al (2022) Targeting the P2Y(13) receptor suppresses IL-33 and HMGB1 release and ameliorates experimental asthma. Am J Respir Crit Care Med 205(3):300–312

    Article  CAS  Google Scholar 

  5. Werder RB, Zhang V, Lynch JP, Snape N, Upham JW, Spann K et al (2018) Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity. J Allergy Clin Immunol 141(5):1607–19.e9

    Article  CAS  Google Scholar 

  6. Popovic PJ, DeMarco R, Lotze MT, Winikoff SE, Bartlett DL, Krieg AM, et al. High mobility group B1 protein suppresses the human plasmacytoid dendritic cell response to TLR9 agonists. Journal of immunology (Baltimore, Md:1950). 2006;177(12):8701–7

  7. To T, Stanojevic S, Moores G, Gershon AS, Bateman ED, Cruz AA et al (2012) Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health. 12:204

    Article  Google Scholar 

  8. Ullemar V, Magnusson PK, Lundholm C, Zettergren A, Melén E, Lichtenstein P et al (2016) Heritability and confirmation of genetic association studies for childhood asthma in twins. Allergy 71(2):230–238

    Article  CAS  Google Scholar 

  9. Ferreira MA, Jansen R, Willemsen G, Penninx B, Bain LM, Vicente CT et al (2017) Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling. J Allergy Clin Immunol 139(4):1148–1157

    Article  CAS  Google Scholar 

  10. Virgilio FD, Sarti AC, Coutinho-Silva R (2020) Purinergic signaling, DAMPs, and inflammation. Am J Physiol Cell Physiol 318(5):C832–C835

    Article  Google Scholar 

  11. Drake LY, Kita H (2017) IL-33: biological properties, functions, and roles in airway disease. Immunol Rev 278(1):173–184

    Article  CAS  Google Scholar 

  12. Hechler B, Vigne P, Léon C, Breittmayer JP, Gachet C, Frelin C (1998) ATP derivatives are antagonists of the P2Y1 receptor: similarities to the platelet ADP receptor. Mol Pharmacol 53(4):727–733

    Article  CAS  Google Scholar 

  13. Kim YC, Lee JS, Sak K, Marteau F, Mamedova L, Boeynaems JM et al (2005) Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor. Biochem Pharmacol 70(2):266–274

    Article  CAS  Google Scholar 

  14. Kudo M, Ishigatsubo Y, Aoki I (2013) Pathology of asthma. Front Microbiol 4:263

    Article  Google Scholar 

  15. Lynch JP, Werder RB, Simpson J, Loh Z, Zhang V, Haque A et al (2016) Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity. J Allergy Clin Immunol 138(5):1326–1337

    Article  CAS  Google Scholar 

  16. APA Thompson RJ, Sayers I, Kuokkanen K, & Hall IP (2021) Purinergic receptors in the airways: potential therapeutic targets for asthma?. Frontiers in Allergy, 2, 16.

  17. Tung H-Y, Plunkett B, Huang S-K, Zhou Y (2014) Murine mast cells secrete and respond to interleukin-33. J Interferon Cytokine Res 34(3):141–147

    Article  CAS  Google Scholar 

  18. Gao Z-G, Ding Y, Jacobson KA (2010) P2Y13 receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells. Pharmacol Res 62(6):500–505

    Article  CAS  Google Scholar 

Download references

Funding

SF receives support from The Nepean Medical Research Fund, The University of Sydney.

Author information

Authors and Affiliations

  1. Department of Medicine, Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Penrith, NSW, 2750, Australia

    Lanxin Li & Stephen J. Fuller

Authors
  1. Lanxin Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephen J. Fuller
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stephen J. Fuller.

Ethics declarations

Ethics approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, L., Fuller, S.J. Inhibiting the P2Y13 receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma. Purinergic Signalling 18, 403–405 (2022). https://doi.org/10.1007/s11302-022-09859-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11302-022-09859-1

Search

Navigation