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A major role for adenosine A2A receptor in the interaction between astrocytes and myelinated neurons: possible implications for the therapy of neurodegenerative disorders

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References

  1. Lezmy J, Arancibia-Cárcamo IL, Quintela-López T, et al (2021) Astrocyte Ca2+-evoked ATP release regulates myelinated axon excitability and conduction speed. Science (80-) 374:. https://doi.org/10.1126/science.abh2858

  2. Lundgaard I, Osório MJ, Kress BT et al (2014) White matter astrocytes in health and disease. Neuroscience 276:161–173. https://doi.org/10.1016/j.neuroscience.2013.10.050

    Article  CAS  PubMed  Google Scholar 

  3. Gomes CV, Kaster MP, Tomé AR et al (2011) Adenosine receptors and brain diseases: neuroprotection and neurodegeneration. Biochim Biophys Acta - Biomembr 1808:1380–1399. https://doi.org/10.1016/J.BBAMEM.2010.12.001

    Article  CAS  Google Scholar 

  4. Sachdeva S, Gupta M (2013) Adenosine and its receptors as therapeutic targets: an overview. Saudi Pharm J 21:245–253. https://doi.org/10.1016/j.jsps.2012.05.011

    Article  PubMed  Google Scholar 

  5. Klinger M, Freissmuth M, Nanoff C (2002) Adenosine receptors: G protein-mediated signalling and the role of accessory proteins. Cell Signal 14:99–108. https://doi.org/10.1016/S0898-6568(01)00235-2

    Article  CAS  PubMed  Google Scholar 

  6. Tebano MT, Martire A, Potenza RL et al (2008) Adenosine A 2A receptors are required for normal BDNF levels and BDNF-induced potentiation of synaptic transmission in the mouse hippocampus. J Neurochem 1:279–286. https://doi.org/10.1111/j.1471-4159.2007.05046.x

    Article  CAS  Google Scholar 

  7. Stevens B, Porta S, Haak LL et al (2002) Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials. Neuron 36:855–868. https://doi.org/10.1016/S0896-6273(02)01067-X

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kao YH, Lin MS, Chen CM et al (2017) Targeting ENT1 and adenosine tone for the treatment of Huntington’s disease. Hum Mol Genet 26:467–478. https://doi.org/10.1093/HMG/DDW402

    Article  CAS  PubMed  Google Scholar 

  9. Boison D (2011) Modulators of nucleoside metabolism in the therapy of brain diseases. Curr Top Med Chem 11:1068–1086. https://doi.org/10.2174/156802611795347609

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Zhou S, Davidson C, McGlynn R et al (2011) Endosomal/lysosomal processing of gangliosides affects neuronal cholesterol sequestration in Niemann-Pick disease type C. Am J Pathol 179:890–902. https://doi.org/10.1016/J.AJPATH.2011.04.017

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Sandau US, Yahya M, Bigej R et al (2019) Transient use of a systemic adenosine kinase inhibitor attenuates epilepsy development in mice. Epilepsia 60:615–625. https://doi.org/10.1111/EPI.14674

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ferrante A, Pezzola A, Matteucci A et al (2018) The adenosine A 2A receptor agonist T1–11 ameliorates neurovisceral symptoms and extends the lifespan of a mouse model of Niemann-Pick type C disease. Neurobiol Dis 110:1–11. https://doi.org/10.1016/j.nbd.2017.10.013

    Article  CAS  PubMed  Google Scholar 

  13. Rissanen E, Virta JR, Paavilainen T et al (2013) Adenosine A2A receptors in secondary progressive multiple sclerosis: a [11C]TMSX brain PET study. J Cereb Blood Flow Metab 33:1394–1401. https://doi.org/10.1038/jcbfm.2013.85

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Akbari A, Khalili-Fomeshi M, Ashrafpour M et al (2018) Adenosine A 2A receptor blockade attenuates spatial memory deficit and extent of demyelination areas in lyolecithin-induced demyelination model. Life Sci 205:63–72. https://doi.org/10.1016/J.LFS.2018.05.007

    Article  CAS  PubMed  Google Scholar 

  15. Duan W, Gui L, Zhou Z et al (2009) Adenosine A2A receptor deficiency exacerbates white matter lesions and cognitive deficits induced by chronic cerebral hypoperfusion in mice. J Neurol Sci 285:39–45. https://doi.org/10.1016/J.JNS.2009.05.010

    Article  CAS  PubMed  Google Scholar 

  16. Yao SQ, Li ZZ, Huang QY et al (2012) Genetic inactivation of the adenosine A2A receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitis. J Neurochem 123:100–112. https://doi.org/10.1111/J.1471-4159.2012.07807.X

    Article  CAS  PubMed  Google Scholar 

  17. Mills JH, Kim D-G, Krenz A et al (2012) A2A adenosine receptor signaling in lymphocytes and the central nervous system regulates inflammation during experimental autoimmune encephalomyelitis. J Immunol 188:5713–5722. https://doi.org/10.4049/jimmunol.1200545

    Article  CAS  PubMed  Google Scholar 

  18. Chen Y, Zhang ZX, Zheng LP, et al (2019) The adenosine A 2A receptor antagonist SCH58261 reduces macrophage/microglia activation and protects against experimental autoimmune encephalomyelitis in mice. Neurochem Int 129https://doi.org/10.1016/J.NEUINT.2019.104490

  19. Coppi E, Cellai L, Maraula G et al (2013) Adenosine A2A receptors inhibit delayed rectifier potassium currents and cell differentiation in primary purified oligodendrocyte cultures. Neuropharmacology 73:301–310. https://doi.org/10.1016/J.NEUROPHARM.2013.05.035

    Article  CAS  PubMed  Google Scholar 

  20. Bernardo A, De Nuccio C, Visentin S et al (2021) Myelin defects in Niemann-Pick type C disease: mechanisms and possible therapeutic perspectives. Int J Mol Sci 22:8858. https://doi.org/10.3390/ijms22168858

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Funding

ZB is a Postdoctoral Fellow supported by FRAXA Research Foundation. ZB, VC and AM are supported by Istituto Superiore di Sanità, intramural funding “Ricerca Corrente”.

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Correspondence to Zaira Boussadia.

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Boussadia, Z., Chiodi, V., Pazienti, A. et al. A major role for adenosine A2A receptor in the interaction between astrocytes and myelinated neurons: possible implications for the therapy of neurodegenerative disorders. Purinergic Signalling 18, 5–7 (2022). https://doi.org/10.1007/s11302-021-09835-1

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