Abstract
Mast cells are widely recognized as effector cells of allergic inflammatory reactions. They contribute to the pathogenesis of different chronic inflammatory diseases, wound healing, fibrosis, thrombosis/fibrinolysis, and anti-tumor immune responses. In this paper, we summarized the role of P2X and P2Y receptors in mast cell activation and effector functions. Mast cells are an abundant source of ATP which is stored in their granules and secreted upon activation. We discuss the contribution of mast cells to the extracellular ATP release and to the maintenance of extracellular nucleotides pool. Recent publications highlight the importance of purinergic signaling for the pathogenesis of chronic airway inflammation. Therefore, the role of ATP and P2 receptors in allergic inflammation with focus on mast cells was analyzed. Finally, ATP functions as mast cell autocrine/paracrine factor and as messenger in intercellular communication between mast cells, nerves, and glia in the central nervous system.
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Abbreviations
- ART:
-
ADP-ribosyltransferase
- BMMC:
-
Bone marrow-derived mast cell
- CBMC:
-
Cord blood mast cell
- CNS:
-
Central nervous system
- HLMC:
-
Human lung mast cell
- IL:
-
Interleukin
- MIP:
-
Macrophage inflammatory protein
- NAD:
-
Nicotinamide adenine dinucleotide
- NGF:
-
Nerve growth factor
- oATP:
-
Oxidized ATP
- OVA:
-
Ovalbumin
- PAMPS:
-
Pathogen-associated molecular patterns
- PKC:
-
Protein kinase C
- RBL:
-
Rat basophilic leukemia
- RANTES:
-
Regulated on activation, normal T cell expressed and secreted
- SCF:
-
Stem cell factor
- SP:
-
Substance P
- TNFα:
-
Tumor necrosis factor α
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Acknowledgments
We are grateful to Dr. Zane Orinska for critical reading of the manuscript and to Annette Wallisch for editorial assistance.
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Bulanova, E., Bulfone-Paus, S. P2 receptor-mediated signaling in mast cell biology. Purinergic Signalling 6, 3–17 (2010). https://doi.org/10.1007/s11302-009-9173-z
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DOI: https://doi.org/10.1007/s11302-009-9173-z