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Non-Gaussian model-based diffusion-weighted imaging of oral squamous cell carcinoma: associations with Ki-67 proliferation status

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Abstract

Objectives

To investigate possible associations between diffusion-weighted imaging (DWI) parameters derived from a non-Gaussian model fitting and Ki-67 status in patients with oral squamous cell carcinoma (OSCC).

Methods

Twenty-four patients with newly diagnosed OSCC were prospectively recruited. DWI was performed using six b-values (0–2500). The diffusion-related parameters of kurtosis value (K), kurtosis-corrected diffusion coefficient (DK), diffusion heterogeneity (α), distributed diffusion coefficient (DDC), slow diffusion coefficient (Dslow), and apparent diffusion coefficient (ADC) were calculated from four diffusion fitting models. Ki-67 status was categorized as low (Ki-67 percentage score < 20%), middle (20–50%), or high (> 50%). Kruskal–Wallis tests were performed between each non-Gaussian diffusion model parameters and Ki-67 grade.

Results

The Kruskal–Wallis tests revealed that multiple parameters (K, ADC, Dk, DDC and Dslow) showed statistically significant differences between the three levels of Ki-67 status (K: p = 0.020, ADC: p = 0.012, Dk: p = 0.027, DDC: p = 0.007 and Dslow: p = 0.026).

Conclusions

Several non-Gaussian diffusion model parameters and ADC values were significantly associated with Ki-67 status and have potential as promising prognostic biomarkers in patients with OSCC.

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Correspondence to Kazuyuki Minowa.

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The authors declare that they have no conflict of interest.

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This study was approved by the Institutional Review Board of Hokkaido University Hospital under protocol 014-0044.

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Informed consent was obtained from all individual participants included in the study.

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Shima, T., Fujima, N., Yamano, S. et al. Non-Gaussian model-based diffusion-weighted imaging of oral squamous cell carcinoma: associations with Ki-67 proliferation status. Oral Radiol 39, 661–667 (2023). https://doi.org/10.1007/s11282-023-00682-x

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  • DOI: https://doi.org/10.1007/s11282-023-00682-x

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