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Quantitative assessment of the mandibular condyle in patients with diabetes mellitus using diffusion-weighted magnetic resonance imaging

Abstract

Objective

The purpose of this study was to quantitatively assess the mandibular condyle in patients with diabetes mellitus (DM) using the apparent diffusion coefficient (ADC) on diffusion-weighted magnetic resonance imaging (DWI).

Study Design

102 patients with DM and temporomandibular joint (TMJ) pain who underwent magnetic resonance imaging (MRI) examination of the TMJs at our hospital between August 2006 and March 2020 were included in this study. 112 patients with temporomandibular disorders (TMD) who underwent MRI examination at our hospital between April 2019 and March 2020 were included as controls. The MRI findings were compared between the two groups.

Results

The mean ADC values of the mandibular condyle in patients with DM were significantly greater than the controls (P < 0.01). Receiver operating characteristic (ROC) curve analysis revealed a cutoff of 0.98 for the ADC values of the mandibular condyle in patients with DM.

Conclusion

This study found that the ADC on DWI could be used for the quantitative assessment of the mandibular condyle in patients with DM. DWI might serve as a new and noninvasive method to assess the presence of DM.

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Abbreviations

DM:

Diabetes mellitus

T1DM:

Type 1 diabetes mellitus

T2DM:

Type 2 diabetes mellitus

IDF:

International Diabetes Federation

IL-6:

Interleukin-6

TMJ:

Temporomandibular joint

TMD:

Temporomandibular disorders

MRI:

Magnetic resonance imaging

ADC:

Apparent diffusion coefficient

DWI:

Diffusion weighted magnetic resonance imaging

JDS:

Japan Diabetes Society

ROC:

Receiver operating characteristic

AUC:

Area under the roc curve

ICC:

Intraclass correlation coefficient

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

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Corresponding author

Correspondence to Naohisa Hirahara.

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Conflict of interest

I have no financial relationships to disclose.

Animal statements

This article does not contain any studies with animal subjects performed by the any of the authors.

Ethics approval

We designed and conducted a retrospective cohort study, which was approved by nihon university ethics committee (EC15-12-009-1).

Informed consent

All procedures followed the guidelines of the Declaration of Helsinki, Ethical Principles for Medical Research Involving Human Subjects.

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Hirahara, N., Muraoka, H., Ito, K. et al. Quantitative assessment of the mandibular condyle in patients with diabetes mellitus using diffusion-weighted magnetic resonance imaging. Oral Radiol (2022). https://doi.org/10.1007/s11282-021-00585-9

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  • DOI: https://doi.org/10.1007/s11282-021-00585-9

Keywords

  • Diabetes mellitus
  • Temporomandibular joint
  • Magnetic resonance imaging
  • Diffusion weighted magnetic resonance imaging
  • Apparent diffusion coefficient value