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Panoramic radiographic features that predict the development of bisphosphonate-related osteonecrosis of the jaw

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Abstract

Objectives

The purpose of this study was to clarify which panoramic radiographic features can predict the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ).

Methods

Participants included 24 patients treated with bisphosphonates (BP) for osteoporosis who developed osteonecrosis of the jaw (ONJ+ group). Controls included 179 patients treated with BP who did not have osteonecrosis (ONJ− group) and 200 patients with no history of BP administration (unmedicated group). The mandibular cortical width, mandibular cortical index (MCI), sclerosis of trabecular bone, and thickening of the lamina dura were evaluated on panoramic radiographs.

Results

The mandibular cortical width was significantly smaller in the ONJ– group than in the other groups. Class II MCI (semilunar defects of endosteal margin) was frequently noted on the affected and contralateral sides in the ONJ+ group but not in the ONJ− or unmedicated groups. Sclerosis of the trabecular bone was significantly more frequently observed on the affected side in the ONJ+ group than in the other groups. Thickening of the lamina dura was observed significantly more frequently in the BP-treated groups than in the unmedicated group.

Conclusions

Class II MCI may be an indicator to predict the development of BRONJ. Sclerosis of trabecular bone was a characteristic imaging feature of BRONJ. Thickening of the lamina dura may be an imaging feature caused by BP administration.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Radiology, Aichi-Gakuin University School of Dentistry, 2-11 Suemori-dori, Chikusa-ku, Nagoya, 464-8651, Japan

    Ryota Kubo, Yoshiko Ariji, Michihito Nozawa & Eiichiro Ariji

  2. Department of Oral and Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Japan

    Tohru Taniguchi

  3. Department of Oral Radiology, Asahi University School of Dentistry, Mizuho, Japan

    Akitoshi Katsumata

Authors
  1. Ryota Kubo
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  2. Yoshiko Ariji
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  3. Tohru Taniguchi
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  4. Michihito Nozawa
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  5. Akitoshi Katsumata
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  6. Eiichiro Ariji
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Corresponding author

Correspondence to Yoshiko Ariji.

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Funding

The authors received no funding for this study.

Conflict of interest

Ryota Kubo, Yoshiko Ariji, Tohru Taniguchi, Michihito Nozawa, Akitoshi Katsuma, and Eiichiro Ariji declare that they have no conflicts of interest.

Human rights statements

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions.

Informed consent

Informed consent was obtained from all patients for being included in the study.

Animal rights statement

This article does not contain any studies with human or animal subjects performed by any of the authors. Panoramic radiographic features predict the development of bisphosphonate-related osteonecrosis of the jaw.

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Kubo, R., Ariji, Y., Taniguchi, T. et al. Panoramic radiographic features that predict the development of bisphosphonate-related osteonecrosis of the jaw. Oral Radiol 34, 151–160 (2018). https://doi.org/10.1007/s11282-017-0293-9

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  • DOI: https://doi.org/10.1007/s11282-017-0293-9

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