Abstract
With the rise of antibiotic resistance globally, coupled with evolving and emerging infectious diseases, there is an urgent need for the development of novel antimicrobials. Deep eutectic solvents (DES) are a new generation of eutectic mixtures that depict promising attributes with several biological implications. DES exhibit unique properties such as low toxicity, biodegradability, and high thermal stability. Herein, the antimicrobial properties of DES and their mechanisms of action against a range of microorganisms, including bacteria, amoebae, fungi, viruses, and anti-cancer properties are reviewed. Overall, DES represent a promising class of novel antimicrobial agents as well as possessing other important biological attributes, however, future studies on DES are needed to investigate their underlying antimicrobial mechanism, as well as their in vivo effects, for use in the clinic and public at large.
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Ruqaiyyah Siddiqui and Naveed Ahmed Khan are supported by the Air Force Office of Scientific Research (AFOSR).
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RS and NAK conceptualized the study amid critical discussions with TI and MK. AK reviewed the literature under supervision of RS and NAK. AK and RS prepared the first draft that was corrected by NAK, AA, TI and MK. All authors approved the final manuscript and will act as guarantors.
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Siddiqui, R., Khodja, A., Ibrahim, T. et al. The increasing importance of novel deep eutectic solvents as potential effective antimicrobials and other medicinal properties. World J Microbiol Biotechnol 39, 330 (2023). https://doi.org/10.1007/s11274-023-03760-8
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DOI: https://doi.org/10.1007/s11274-023-03760-8