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Recent developments in siderotyping: procedure and application

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Abstract

Siderophores are metal chelating secondary metabolites secreted by almost all organisms. Beside iron starvation, the ability to produce siderophores depends upon several other factors. Chemical structure of siderophore is very complex with vast structural diversity, thus the principle challenge involves its detection, quantification, purification and characterisation. Metal chelation is its most fascinating attribute. This metal chelation property is now forming the basis of its application as molecular markers, siderotyping tool for taxonomic clarification, biosensors and bioremediation agents. This has led researchers to develop and continuously modify previous techniques in order to provide accurate and reproducible methods of studying siderophores. Knowledge obtained via computational approaches provides a new horizon in the field of siderophore biosynthetic gene clusters and their interaction with various proteins/peptides. This review illustrates various techniques, bioinformatics tools and databases employed in siderophores’ studies, the principle of analytical methods and their recent applications.

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Acknowledgements

Authors Pratika Singh, Azmi Khan, Ravinsh Kumar and Rakesh Kumar are thankful to the University Grants Commission, New Delhi for providing financial support as fellowship.

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Authors Pratika Singh, Azmi Khan, Ravinsh Kumar and Rakesh Kumar are thankful to the University Grants Commission, New Delhi for providing financial support in the form of non-net fellowship.

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  1. Department of Life Science, School of Earth, Biological and Environmental Sciences, Central University of South Bihar, Gaya, 824236, India

    Pratika Singh, Azmi Khan, Ravinsh Kumar & Amrita Srivastava

  2. Department of Bioinformatics, School of Earth, Biological and Environmental Sciences, Central University of South Bihar, Gaya, 824236, India

    Rakesh Kumar & Vijay Kumar Singh

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  1. Pratika Singh
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Singh, P., Khan, A., Kumar, R. et al. Recent developments in siderotyping: procedure and application. World J Microbiol Biotechnol 36, 178 (2020). https://doi.org/10.1007/s11274-020-02955-7

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