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Harnessing the knowledge of protein secretion for enhanced protein production in filamentous fungi

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Abstract

Filamentous fungi are important microorganisms used in industrial production of proteins and enzymes. Among these organisms, Trichoderma reesei, Aspergilli, and more recently Myceliophthora thermophile are the most widely used and promising ones which have powerful protein secretion capability. In recent years, there have been tremendous achievements in understanding the molecular mechanisms of the secretory pathways in filamentous fungi. The acquired pieces of knowledge can be harnessed to enhance protein production in filamentous fungi with assistance of state-of-the-art genetic engineering techniques.

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Acknowledgements

We are grateful to the funding including the National Key R&D Program of China (2016YFD0501409-02), the National Natural Science Foundation of China Grant 31672458, the Fundamental Research Funds for Central Non-profit Scientific Institution (1610382016004 and Y2017JC31), the National Chicken Industry Technology System of China (CARS-41), and the Elite Youth Program of Chinese Academy of Agricultural Sciences.

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Sun, X., Su, X. Harnessing the knowledge of protein secretion for enhanced protein production in filamentous fungi. World J Microbiol Biotechnol 35, 54 (2019). https://doi.org/10.1007/s11274-019-2630-0

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