Abstract
Nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH), as two kinds of well-known cofactor, are widely used in the most of enzymatic redox reactions, playing an important role in industrial catalysis. In general, supply of NAD(P)H is a major challenged factor in redox fermentation systems due to its high cost and low stability, which have stimulated the development of NADH regeneration systems in recent years. Until now, a series of NAD(P)H regeneration systems have been developed. This review focuses primarily on new approaches of NAD(P)H cofactor regeneration in the biosynthesis systems, such as single cell in vivo NADH regeneration system, double cell coupling NADH regeneration system, in vitro enzyme-coupled NADH regeneration system, microbial cell surface display NADH regeneration system. Finally, the prospect and tendency of NADH regeneration are discussed.
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Abbreviations
- ADH:
-
Alcohol dehydrogenase
- CHMO:
-
Cyclohexanone monooxygenase
- COBE:
-
4-Chloro-3-oxobutanoate
- Coh:
-
Cohesin module
- CohC:
-
Cohesin C
- CohT:
-
Cohesin T
- Combi-CLEAs:
-
Combined cross-linked enzyme aggregates
- DH:
-
Isocitrate dehydrogenase
- DocC:
-
Dockerin C
- Doc:
-
Dockerin module
- DocT:
-
Dockerin T
- EhaA:
-
Autotransporter protein
- ED:
-
Entner–Doudoroff
- ee :
-
Enantiomeric excess
- EMP:
-
Embden–Meyerhof–Parnas
- FNR:
-
Ferredoxin
- FDH:
-
Formate dehydrogenase
- GA:
-
Glucoamylase
- GAPDH:
-
Glyceraldehyde-3-phosphate dehydrogenase
- G6PDH:
-
Glucose 6-phosphate dehydrogenase
- GDH:
-
Glucose dehydrogenase
- GLDH:
-
Glutamate dehydrogenase
- HDH:
-
Hydrogen dehydrogenase
- H+-TH:
-
Membrane-bound transhydrogenase
- INP:
-
Ice nuclear protein
- KR:
-
Ketoreductase
- KRED:
-
Ketoreductase
- LDH:
-
Leucine dehydrogenase
- ME:
-
Malic enzyme
- NADH:
-
Reduced form of nicotinamide adenine dinucleotide
- NADPH:
-
Reduced form of nicotinamide adenine dinucleotide phosphate
- 2 NADK:
-
NAD+ kinase
- NAD(P)H:
-
NADH and NADPH
- 2-PE:
-
2-Phenylethanol
- 1,3-PD:
-
1,3-Propanediol
- γ-PGA:
-
Poly-γ-glutamic acid
- 6PGDH:
-
6-Phosphogluconate dehydrogenase
- POS5:
-
Mitochondrial NADH kinase
- PPP:
-
Pentose phosphate pathway
- RBS:
-
Ribosome binding site
- SH:
-
NADP+-reducing hydrogenases
- STH:
-
Soluble transhydrogenase
- TCA:
-
Tricarboxylic acid
- TMR:
-
Triphenylmethane reductase
- W.E.:
-
Widely existed in most organisms
- XR:
-
Xylose reductase
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Acknowledgements
This work was financially supported by National Natural Science Foundation of China (Grant No. 21705087), Research Foundation for Distinguished Scholars of Qingdao Agricultural University (663-1117015) and A Project of Shandong Province Higher Educational Science and Technology Program (J18KA067).
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Han, L., Liang, B. New approaches to NAD(P)H regeneration in the biosynthesis systems. World J Microbiol Biotechnol 34, 141 (2018). https://doi.org/10.1007/s11274-018-2530-8
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DOI: https://doi.org/10.1007/s11274-018-2530-8