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Recent advances in microbial production of mannitol: utilization of low-cost substrates, strain development and regulation strategies

World Journal of Microbiology and Biotechnology volume 34, Article number: 41 (2018) Cite this article

Abstract

Mannitol has been widely used in fine chemicals, pharmaceutical industries, as well as functional foods due to its excellent characteristics, such as antioxidant protecting, regulation of osmotic pressure and non-metabolizable feature. Mannitol can be naturally produced by microorganisms. Compared with chemical manufacturing, microbial production of mannitol provides high yield and convenience in products separation; however the fermentative process has not been widely adopted yet. A major obstacle to microbial production of mannitol under industrial-scale lies in the low economical efficiency, owing to the high cost of fermentation medium, leakage of fructose, low mannitol productivity. In this review, recent advances in improving the economical efficiency of microbial production of mannitol were reviewed, including utilization of low-cost substrates, strain development for high mannitol yield and process regulation strategies for high productivity.

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Acknowledgements

The Key Science and Technology Project of Jiangsu Province (BE2016389), Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals Foundation (JSBEM2016010).

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Affiliations

  1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People’s Republic of China

    Min Zhang, Lei Gu, Chao Cheng, Jiangfeng Ma, Fengxue Xin, Hao Wu & Min Jiang

  2. State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People’s Republic of China

    Hao Wu & Min Jiang

  3. The Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Puzhu South Road 30#, Nanjing, 211800, People’s Republic of China

    Hao Wu & Min Jiang

  4. Institute of Chemical Industry of Forest Products, Nanjing, 210042, People’s Republic of China

    Junli Liu

Authors
  1. Min Zhang
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  2. Lei Gu
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  3. Chao Cheng
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  4. Jiangfeng Ma
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  5. Fengxue Xin
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  6. Junli Liu
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  7. Hao Wu
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  8. Min Jiang
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Correspondence to Min Jiang.

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Zhang, M., Gu, L., Cheng, C. et al. Recent advances in microbial production of mannitol: utilization of low-cost substrates, strain development and regulation strategies. World J Microbiol Biotechnol 34, 41 (2018). https://doi.org/10.1007/s11274-018-2425-8

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  • DOI: https://doi.org/10.1007/s11274-018-2425-8

Keywords

  • Mannitol
  • Fermentation
  • Strain development
  • Regulation
  • Metabolic flux