Recent advances in microbial production of mannitol: utilization of low-cost substrates, strain development and regulation strategies

  • Min Zhang
  • Lei Gu
  • Chao Cheng
  • Jiangfeng Ma
  • Fengxue Xin
  • Junli Liu
  • Hao Wu
  • Min Jiang


Mannitol has been widely used in fine chemicals, pharmaceutical industries, as well as functional foods due to its excellent characteristics, such as antioxidant protecting, regulation of osmotic pressure and non-metabolizable feature. Mannitol can be naturally produced by microorganisms. Compared with chemical manufacturing, microbial production of mannitol provides high yield and convenience in products separation; however the fermentative process has not been widely adopted yet. A major obstacle to microbial production of mannitol under industrial-scale lies in the low economical efficiency, owing to the high cost of fermentation medium, leakage of fructose, low mannitol productivity. In this review, recent advances in improving the economical efficiency of microbial production of mannitol were reviewed, including utilization of low-cost substrates, strain development for high mannitol yield and process regulation strategies for high productivity.


Mannitol Fermentation Strain development Regulation Metabolic flux 



The Key Science and Technology Project of Jiangsu Province (BE2016389), Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals Foundation (JSBEM2016010).

Compliance with ethical standards

Conflict of interest

The authors declares that they have no conflict of interest.


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© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Min Zhang
    • 1
  • Lei Gu
    • 1
  • Chao Cheng
    • 1
  • Jiangfeng Ma
    • 1
  • Fengxue Xin
    • 1
  • Junli Liu
    • 4
  • Hao Wu
    • 1
    • 2
    • 3
  • Min Jiang
    • 1
    • 2
    • 3
  1. 1.College of Biotechnology and Pharmaceutical EngineeringNanjing Tech UniversityNanjingPeople’s Republic of China
  2. 2.State Key Laboratory of Materials-Oriented Chemical EngineeringNanjing Tech UniversityNanjingPeople’s Republic of China
  3. 3.The Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjingPeople’s Republic of China
  4. 4.Institute of Chemical Industry of Forest ProductsNanjingPeople’s Republic of China

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