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A novel thiazolidinedione derivative TD118 showing selective algicidal effects for red tide control

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Abstract

Thiazolidinedione (TD) derivatives have been found to have an algicidal effect on harmful algal bloom microalgae. In this study, 75 TD derivatives were synthesized and analyzed for algicidal activity. Among these synthetic TDs, 18 TD derivatives showed specific algicidal activity on two strains belonging to the classes Raphidophyceae (Chattonella marina and Heterosigma akashiwo) and Dinophyceae (Cochlodinium polykrikoides). Two strains belonging to Bacillariophyceae (Navicula pelliculosa and Phaeodactylum EPV), one strain belonging to Dinophyceae (Amphidinium sp.), and a Eustigmatophycean microalga (Nannochloropsis oculata) showed less sensitivity to the TD derivatives than the other two phyla. The most reactive TD derivative, compound 2 (TD118), was selected and tested for morphological and physiological changes. TD118 effectively damaged the cell membrane of C. marina, H. akashiwo and C. polykrikoides. The O2 evolution and photosystem II efficiency (F v /F m ) of C. marina, H. akashiwo and C. polykrikoides were also severely reduced by TD118 treatment. Amphidinium sp., N. pelliculosa, Phaeodactylum EPV and N. oculata showed less reduction of O2 evolution and the F v /F m by TD118. These results imply that the species-specific TD structure relationship may be due to structural and/or physiological differences among microalgal species.

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Acknowledgments

This work was supported by the Pioneer Research Center Program through the National Research Program of Korea (Grant No. 2008-2000122), the National Research Foundation of Korea Grant (NRF-C1ABA001-2010-0020501) and the Korea CCS R&D Center (KCRC) grant  (No. 2011-0031999) funded by the Korea Government (Ministry of Science, ICT and Future Planning).

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Authors and Affiliations

  1. Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, 133-791, Korea

    Yew Lee, Seul-Gi Jung, Minju Kim & EonSeon Jin

  2. Department of Polymer Science and Engineering, Chosun University, Kwangju, 501-759, Korea

    Ying Wu & Hoon Cho

  3. Seoul Center, Korea Basic Science Institute, Seoul, 136-713, Korea

    Chi-Yong Eom

  4. Department of Environmental Engineering, Chosun University, Kwangju, 501-759, Korea

    Si Wouk Kim

Authors
  1. Ying Wu
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  2. Yew Lee
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  3. Seul-Gi Jung
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  4. Minju Kim
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  5. Chi-Yong Eom
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  6. Si Wouk Kim
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  7. Hoon Cho
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  8. EonSeon Jin
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Corresponding authors

Correspondence to Hoon Cho or EonSeon Jin.

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Ying Wu and Yew Lee have contributed equally to this work.

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Wu, Y., Lee, Y., Jung, SG. et al. A novel thiazolidinedione derivative TD118 showing selective algicidal effects for red tide control. World J Microbiol Biotechnol 30, 1603–1614 (2014). https://doi.org/10.1007/s11274-013-1584-x

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  • DOI: https://doi.org/10.1007/s11274-013-1584-x

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