Comparative analysis of flavonoids and polar metabolites from hairy roots of Scutellaria baicalensis and Scutellaria lateriflora


Baicalin, baicalein, and wogonin were accumulated in hairy roots derived from Scutellaria lateriflora and Scutellaria baicalensis. The levels of baicalein and baicalin were 6.8 and 5.0 times higher, respectively, in S. baicalensis than in S. lateriflora. A total of 47 metabolites were detected and identified in Scutellaria species by GC-TOF MS. The metabolites from the two species were subjected to principal component analysis (PCA) to evaluate differences. PCA fully distinguished between the two species. The results showed that individual phenolic acids and phenylalanine, precursors for the phenylpropanoid biosynthetic pathway, were higher in S. baicalensis than in S. lateriflora. This GC-TOF MS-based metabolic profiling approach was a viable alternative method to differentiate metabolic profiles between species.

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This work (K13101) was supported by the Korea Institute of Oriental Medicine (KIOM) grant funded by the Korea government and in part this study was supported by the National Academy of Agricultural Science (Code PJ0068342012), Rural Development Administration, Republic of Korea.

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Correspondence to Sun Ok Chung or Sang Un Park.

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Jae Kwang Kim and Young Seon Kim have contributed equally to this work.

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Kim, J.K., Kim, Y.S., Kim, Y. et al. Comparative analysis of flavonoids and polar metabolites from hairy roots of Scutellaria baicalensis and Scutellaria lateriflora . World J Microbiol Biotechnol 30, 887–892 (2014).

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  • Hairy root culture
  • Metabolomics
  • Principal component analysis
  • Scutellaria baicalensis
  • Scutellaria lateriflora