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Summing up particular features of protein secretion in Streptomyces lividans

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Abstract

In recent years much attention has been given to the identification and characterisation of the key elements of the secretory machinery of Streptomyces lividans, a non-pathogenic filamentous Gram-positive soil bacterium, whose metabolism is relatively well characterised and capable of secreting large amounts of proteins when grown in laboratory conditions. The relevance of S. lividans from a commercial standpoint is due to its potential usefulness for the overproduction of secretory homologous and heterologous proteins of interest. Therefore, this review focuses on the knowledge already obtained on the S. lividans secretion pathways.

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Acknowledgments

Grants BIO2003-03948 and BIO2006-12762 from the Spanish Ministry of Science and Innovation have supported this work.

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  1. Centro Nacional de Biotecnología (CSIC), c/Darwin 3, Campus de la Universidad Autónoma, Cantoblanco, 28049, Madrid, Spain

    Rafael P. Mellado

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  1. Rafael P. Mellado
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Correspondence to Rafael P. Mellado.

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Mellado, R.P. Summing up particular features of protein secretion in Streptomyces lividans . World J Microbiol Biotechnol 27, 2231–2237 (2011). https://doi.org/10.1007/s11274-011-0709-3

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