Abstract
Two metabolites were obtained by microbial transformation of androstendione in the culture of Aspergillus terreus PTCC 5283, a fungus isolated from soil. Their structures were established as testosterone and testololactone on the basis of the spectral data including 1H NMR, 13C NMR, FTIR, MS and physical constants such as melting point and optical rotation. Aspergillus terreusproduced both metabolites after 3 days incubation at 27 °C. The bioconversion reactions observed were 17-carbonyl reduction and biological Baeyer–Villiger oxidation.
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Faramarzi, M.A., Yazdi, M.T., Amini, M. et al. Microbial production of testosterone and testololactone in the culture of Aspergillus terreus . World Journal of Microbiology and Biotechnology 20, 657–660 (2004). https://doi.org/10.1007/s11274-004-1003-4
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DOI: https://doi.org/10.1007/s11274-004-1003-4