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Zika virus infection induces expression of NRF2 and antioxidant systems in trophoblast cells

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Abstract

The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays a critical role in the xenobiotic and stress responses. During viral infection, NRF2 can modulate the host metabolism and innate immunity; however, the most common activity of NRF2 in viral diseases is controlling reactive oxygen species (ROS). The Zika virus (ZIKV) is involved in a vertical infection in pregnancy, with reported fetal health consequences. However, the possibility that ZIKV regulates NRF2 expression in placental trophoblasts has not been investigated. In this report, we evaluated the upregulation of NRF2 and antioxidant enzymes in a trophoblast-like cell. These findings could help us understand the antioxidant mechanism underlying the ZIKV infection in the placenta during pregnancy.

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Fig. 1 

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Acknowledgements

This research was funded by the Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, 212250-3210-21007-03-16. H.A.R., O.L.O., A.M.E., M.M.C., G.L.R.,A.C.H.R., J.G.C., and M.L.J. acknowledge their membership of the National System of Researchers (SNI).

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Author notes

  1. Manuel Adrián Velázquez Cervantes and Julio Angel Vázquez Martinez contributed equally to this work.

Authors and Affiliations

  1. Laboratorio de Virologia Perinatal y Diseño Molecular de Antigenos y Biomarcadores, Departamento de Inmuno-Bioquímica, Instituto Nacional de Perinatología “Isidro Espinosa de los Reyes”, Ciudad de Mexico, México

    Manuel Adrián Velázquez Cervantes, Luis Didider Gonzalez García & Moisés León Juárez

  2. Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL, USA

    Julio Angel Vázquez Martinez

  3. Institut National de la Santé et de la Recherche Médicale (INSERM) U1151, Institut Necker Enfants Malades, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Orestes Lopez Ortega

  4. Laboratorio de Inmunología y Microbiología Molecular, División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Mexico

    Haruki Arevalo Romero

  5. Coordinación de Ginecología y Endocrinología Perinatal, Instituto Nacional de Perinatología “Isidro Espinosa de los Reyes”, Ciudad de Mexico, Mexico

    Araceli Montoya Estrada

  6. Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Casco de Santo Tomas, 11340, Ciudad de Mexico, Mexico

    Macario Martínez Castillo

  7. Departamento de Inmuno-Bioquímica, Instituto Nacional de Perinatología “Isidro Espinosa de los Reyes”, Ciudad de Mexico, Mexico

    Arturo Flores Pliego & Addy Cecilia Helguera Repetto

  8. Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica, Ciudad de Mexico, Mexico

    Guadalupe León Reyes

  9. Departamento de Biomedicina Molecular, CINVESTAV IPN, Av. IPN # 2508 Col. San Pedro Zacatenco, 07360, México, D.F., Mexico

    Julio García Cordero

Authors
  1. Manuel Adrián Velázquez Cervantes
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  2. Julio Angel Vázquez Martinez
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  3. Luis Didider Gonzalez García
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  4. Orestes Lopez Ortega
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  5. Haruki Arevalo Romero
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  6. Araceli Montoya Estrada
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  7. Macario Martínez Castillo
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  8. Arturo Flores Pliego
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  9. Guadalupe León Reyes
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  10. Addy Cecilia Helguera Repetto
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  11. Julio García Cordero
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  12. Moisés León Juárez
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Contributions

Conceptualization, MLJ; MAVC; JAVM and JGC. Methodology, LDGG; MAVC; JAVM; AME; JGC and AFP. Formal analysis, MMC; GLR and HAR. Writing original draft preparation, JAVM; and MLJ. Writing review and editing, MMC; JAVM; OLO; ACHR and MLJ. Supervision, MLJ. Project administration MLJ. Funding acquisition, MLJ.

Corresponding author

Correspondence to Moisés León Juárez.

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All authors declare that no conflicts of interest exist.

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This article does not contain any study with human participants or animals, performed by any of the authors.

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Edited by Joachim J. Bugert.

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Cervantes, M.A.V., Martinez, J.A.V., García, L.D.G. et al. Zika virus infection induces expression of NRF2 and antioxidant systems in trophoblast cells. Virus Genes 59, 781–785 (2023). https://doi.org/10.1007/s11262-023-02014-x

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  • DOI: https://doi.org/10.1007/s11262-023-02014-x

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