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First complete genome sequence of Asia-4 lineage of canine distemper virus in China

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Abstract

We previously reported a novel Asia-4 lineage of canine distemper virus (CDV) in China based on the H gene. In the present study, a Chinese CDV NJ(11)2 strain of the Asia-4 lineage from Nanjing, China was isolated and its whole genome sequence was obtained. The CDV NJ(11)2 strain clustered with the Thai strains of the Asia-4 lineage in the phylogenetic tree of the complete genome. Phylogenetic analysis based on six individual genes also revealed that the CDV NJ(11)2 strain belonged to Asia-4 lineage. According to the individual N and H genes, two Chinese strains XJ4 from Xinjiang and C11 from Chengdu were clustered with the Asia-4 lineage. These results suggested that the Asia-4 lineage of CDV appeared in the three regions of China. Interestingly, Chinese BJ16B35 strain was identified as a novel putative recombinant virus from a major parent virus of the Asia-1 lineage and a minor parent virus of the America-1 lineage. The first genome sequence of Chinese Asia-4 lineage of CDV contributes to the knowledge of the evolution and molecular epidemiology of CDV infection.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (31802168).

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Authors and Affiliations

  1. Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture and Rural Affairs, National Center for Engineering Research of Veterinary Bio-Products, Nanjing, 210014, China

    Zhenwei Bi

  2. Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China

    Zhenwei Bi

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  1. Zhenwei Bi
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Correspondence to Zhenwei Bi.

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Bi, Z. First complete genome sequence of Asia-4 lineage of canine distemper virus in China. Virus Genes 58, 59–69 (2022). https://doi.org/10.1007/s11262-021-01883-4

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  • DOI: https://doi.org/10.1007/s11262-021-01883-4

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