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Genotypes of rhinovirus detected among children in two communities of South-West Nigeria

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Abstract

Rhinoviruses (RVs) are the most common etiological agent implicated in respiratory infections among infants and children. There are currently no approved antivirals and vaccine for use against the virus; hence, the need for information on the genotypes of rhinovirus from developing countries of the world with high burden of the infection. This study determined the genotypes of rhinovirus circulating among children in selected cities in Nigeria. Nasopharyngeal and oropharyngeal samples were carefully collected from children showing signs of respiratory infection in two communities in South-west Nigeria. Polymerase Chain Reaction was used to amplify the hypervariable part of the 5'- non-coding region, the entire viral protein gene 4 and the 5' terminus of the VP2 gene of RV. Nucleotide BLAST and phylogenetic analyses were used to genotype the isolates. Of the samples analysed, 12.7% showed rhinovirus positivity. All the three genotypes of rhinovirus were detected with genotype C (71.4%), being the predominant. Multiple strains of rhinovirus were found circulating. We showed for the first time the genotypes and strains of rhinovirus circulating in Nigeria. Further studies are required to highlight transmission patterns and disease severity among rhinovirus species in Nigeria.

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Fig. 1

Data availability

All data generated or analysed during this study are included in this published article and the nucleotide sequence of the study isolates (Accession numbers MH746715-MH746727) can be obtained in Genbank.

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Funding

No funding was received for conducting this study.

Author information

Authors and Affiliations

  1. Department of Virology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria

    Olukunle O. Oluwasemowo & Babatunde O. Motayo

  2. Microbiology Programme, College of Agriculture, Engineering and Science, Bowen University, Iwo, Osun State, Nigeria

    Yewande T. Nejo, Josephine O. Abokede & Michael Lawson

  3. Department of Medical Microbiology, Federal Medical Center, Abeokuta, Ogun State, Nigeria

    Babatunde O. Motayo

Authors
  1. Olukunle O. Oluwasemowo
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  2. Yewande T. Nejo
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  3. Josephine O. Abokede
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  4. Michael Lawson
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  5. Babatunde O. Motayo
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Contributions

Conceptualization, OOO and YTN; Methodology, OOO and YTN; Formal Analysis, OOO; Investigation, OOO and YTN; Resources, OOO, YTN, JOA and ML; Data Curation, OOO, YTN, JOA and ML; Writing—Original Draft Preparation, OOO; Writing—Review & Editing, OOO, YTN and BOM; Supervision, OOO and YTN.

Corresponding authors

Correspondence to Olukunle O. Oluwasemowo or Yewande T. Nejo.

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Conflict of interest

The authors have no conflicts of interest to declare that are relevant to the content of this article.

Ethical approval

The study was approved by the University of Ibadan/University College Hospital ethics committee with approval number UI/EC/14/0284.

Consent to participate

Informed assent was obtained from parents/guardian of the participants.

Additional information

Edited by Joachim Jakob Bugert.

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Oluwasemowo, O.O., Nejo, Y.T., Abokede, J.O. et al. Genotypes of rhinovirus detected among children in two communities of South-West Nigeria. Virus Genes 57, 276–279 (2021). https://doi.org/10.1007/s11262-021-01841-0

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  • DOI: https://doi.org/10.1007/s11262-021-01841-0

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