Skip to main content

Advertisement

SpringerLink
Log in

Phylogenetic analysis of a transfusion-transmitted hepatitis A outbreak

  • Published:
Virus Genes Aims and scope Submit manuscript

Abstract

A transfusion-associated hepatitis A outbreak was found in the first time in Hungary. The outbreak involved five cases. Parenteral transmission of hepatitis A is rare, but may occur during viraemia. Direct sequencing of nested PCR products was performed, and all the examined samples were identical in the VP1/2A region of the hepatitis A virus genome. HAV sequences found in recent years were compared and phylogenetic analysis showed that the strain which caused these cases is the same as that had spread in Hungary recently causing several hepatitis A outbreaks throughout the country.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. A. Dotzauer, A. Heitmann, T. Laue, L. Kraemer, K. Schwabe, D. Paulmann, B. Flehmig, A. Vallbracht, J. Gen. Virol. 93(Pt 4), 754–760 (2012)

    Article  CAS  PubMed  Google Scholar 

  2. T.Y. Bondarenko, V.A. Ternovoi, S.V. Netesov, Mol. Genet. Microbiol. Virol. 28(3), 99–109 (2013)

    Article  Google Scholar 

  3. M. Costa-Mattioli, J. Cristina, H. Romero, R. Perez-Bercof, D. Casane, R. Colina, L. Garcia, I. Vega, G. Glikman, V. Romanowsky, A. Castello, E. Nicand, M. Gassin, S. Billaudel, V. Ferré, J. Virol. 76(18), 9516–9525 (2002)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. F. Corpet, Nucl. Acids Res. 16(22), 10881–10890 (1988)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. K. Tamura, G. Stecher, D. Peterson, A. Filipski, S. Kumar, Mol. Biol. Evol. 30(12), 2725–2729 (2013)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. A.H. Diwan, J.R. Stubbs, G.E. Carnahan, Transfusion 43(4), 536–540 (2003)

    Article  PubMed  Google Scholar 

  7. P. Gowland. S. Fontana, C. Niederhauser, B.M. Taleghani, Transfusion 44(11), 1555–1561 (2004)

    Article  CAS  PubMed  Google Scholar 

  8. J.A. Hughes, A. Jonathan, M.J. Fontaine, C.L. Gonzalez, A.G. Layon, L.T. Goodnough, S.A. Galel, Transfusion 54(9), 2202–2206 (2014)

    Article  PubMed  Google Scholar 

  9. W.A. Bower, O.V. Nainan, X. Han, H.S. Margolis, J. Infect. Dis. 182(1), 12–17 (2000)

    Article  CAS  PubMed  Google Scholar 

  10. L. Zhu, X. Zhang, Protein Cell 6(2), 79–80 (2015)

    Article  PubMed  Google Scholar 

  11. J.M. Soucie, B.H. Robertson, B.P. Bell, K.A. McCaustland, B.L. Evatt, Transfusion 38(6), 573–579 (1998)

    Article  CAS  PubMed  Google Scholar 

  12. M. Chudy, I. Budek, B. Keller-Stanislawski, K.A. McCaustland, S. Neidhold, B.H. Robertson, C.M. Nübling, R. Seitz, J. Löwer, J. Med. Virol. 57(2), 91–99 (1999)

    Article  CAS  PubMed  Google Scholar 

  13. H.G. Klein, J. Intern. Med. 257(3), 224–237 (2005)

    Article  CAS  PubMed  Google Scholar 

  14. T. Weimer, S. Streichert, C. Watson, A. Gröner, J. Med. Virol. 67(4), 469–471 (2002)

    Article  PubMed  Google Scholar 

  15. T. Han, C. Li, Y. Zhang, Y. Wang, B. Wu, L. Ke, G. Liu, L. Li, Y. Liu, Z. Liu, Transfus. Med. 25(6), 406–410 (2015)

    Article  CAS  PubMed  Google Scholar 

  16. S. Modrow, J.J. Wenzel, S. Schimanski, J. Schwarzbeck, U. Rothe, J. Oldenburg, W. Jilg, A.M. Eis-Hübinger. Vox Sang. 100(4), 351–358 (2011)

    Article  CAS  PubMed  Google Scholar 

  17. O. Pohl, J. Brojnás, E. Rusvai, K. Ordög, I. Siska, G. Faludi, B. Kapusinszky, A. Csohán, K. Lendvai, A. Lengyel, I. Mezey, G. Berencsi, FEMS Immunol. Med. Microbiol. 38(1), 85–91 (2013)

    Article  Google Scholar 

  18. C. Phan, F.B. Hollinger, Clin. Liver Dis. 2(6), 231–234 (2013)

    Article  Google Scholar 

  19. K. Stene-Johansen, G. Tjon, E. Schreier, V. Bremer, S. Bruisten, SL. Ngui, M. King, R.M. Pinto, L. Aragonès, A. Mazick, S. Corbet, L. Sundqvist, H. Blystad, H. Norder, K.J. Skaug, J. Med. Virol. 79(4), 356–365 (2007)

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to thank Dr. Gyula Prinz for giving information about clinical data of patients.

Author information

Authors and Affiliations

  1. Division of Virology, National Reference Laboratory for Hepatitis Viruses, National Center for Epidemiology, Albert Flórián út 2-6, Budapest, 1097, Hungary

    Andrea Hettmann, Ágnes Dencs, Bálint Tresó, Erzsébet Rusvai & Mária Takács

  2. Government Office of the Capital City Budapest, Policy Administration Services of Public Health, Budapest, Hungary

    Gabriella Juhász

  3. National Blood Transfusion Service, Budapest, Hungary

    Éva Barabás

Authors
  1. Andrea Hettmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gabriella Juhász
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ágnes Dencs
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bálint Tresó
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Erzsébet Rusvai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Éva Barabás
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mária Takács
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mária Takács.

Additional information

Edited by Hartmut Hengel.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hettmann, A., Juhász, G., Dencs, Á. et al. Phylogenetic analysis of a transfusion-transmitted hepatitis A outbreak. Virus Genes 53, 15–20 (2017). https://doi.org/10.1007/s11262-016-1392-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11262-016-1392-0

Keywords

Search

Navigation