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Discovery of new feline paramyxoviruses in domestic cats with chronic kidney disease

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Abstract

Paramyxoviruses constitute a large family of enveloped RNA viruses including important pathogens in veterinary and human medicine. Recently, feline paramyxoviruses, genus morbillivirus, were detected in cats from Hong Kong and Japan. Here we describe the discovery of several new feline paramyxoviruses. Infections with these diverse viruses were detected in urine samples from cats suffering from chronic kidney disease (CKD). No viral RNA was found in cats without clinical signs of uropathy highlighting an association between feline paramyxovirus (FPaV) infections and CKD. Phylogenetic analyses of the detected viruses showed that they represent at least two different species, one of them representing the feline morbilliviruses detected previously in Hong Kong and Japan. In addition, a new FPaV was detected sharing only 73 % homology on the nucleotide level of the viral L-gene to currently known paramyxoviral species.

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Acknowledgments

The authors thank Ines Müller and Grit Müller for excellent assistance in collecting urine samples and in providing urinalysis data from the cats investigated in this study.

Author contributions

T W. Vahlenkamp designed and supervised the study and revised the manuscript, M. Sieg performed experimental work, interpreted all of the data and wrote the manuscript draft. Antje Rueckner and Kristin Heenemann assisted in virus isolation attempts and in the preparation of primary cells. I. Burgener and G. Oechtering supervised sample collection and provided clinical data of diseased animals.

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Correspondence to Thomas W. Vahlenkamp.

Additional information

Edited by William Dundon.

Nucleotide sequences accession numbers: KP159802, KP159803, KP159804, KP159805, KR269598, KR269599, KR269600 and KR269601.

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Sieg, M., Heenemann, K., Rückner, A. et al. Discovery of new feline paramyxoviruses in domestic cats with chronic kidney disease. Virus Genes 51, 294–297 (2015). https://doi.org/10.1007/s11262-015-1232-7

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  • DOI: https://doi.org/10.1007/s11262-015-1232-7

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