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Recombination among human non-polio enteroviruses: implications for epidemiology and evolution

Virus Genes volume 50, pages 177–188 (2015)Cite this article

Abstract

Human enteroviruses (EV) belong to the Picornaviridae family and are among the most common viruses infecting humans. They consist of up to 100 immunologically and genetically distinct types: polioviruses, coxsackieviruses A and B, echoviruses, and the more recently characterized 43 EV types. Frequent recombinations and mutations in enteroviruses have been recognized as the main mechanisms for the observed high rate of evolution, thus enabling them to rapidly respond and adapt to new environmental challenges. The first signs of genetic exchanges between enteroviruses came from polioviruses many years ago, and since then recombination has been recognized, along with mutations, as the main cause for reversion of vaccine strains to neurovirulence. More recently, non-polio enteroviruses became the focus of many studies, where recombination was recognized as a frequent event and was correlated with the appearance of new enterovirus lineages and types. The accumulation of multiple inter- and intra-typic recombination events could also explain the series of successive emergences and disappearances of specific enterovirus types that could in turn explain the epidemic profile of circulation of several types. This review focuses on recombination among human non-polio enteroviruses from all four species (EV-A, EV-B, EV-C, and EV-D) and discusses the recombination effects on enterovirus epidemiology and evolution.

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Abbreviations

AFP:

Acute flaccid paralysis

CV-A:

Coxsackievirus A

CV-B:

Coxsackievirus B

E:

Echovirus

EV:

Enterovirus

EV-A:

Enterovirus A

EV-B:

Enterovirus B

EV-C:

Enterovirus C

EV-D:

Enterovirus D

HFMD:

Hand foot and mouth disease

IRES:

Internal ribosome entry site

PV:

Poliovirus

RF:

Recombinant form

UTR:

Untranslated region

VDPVs:

Vaccine-derived polioviruses

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Acknowledgments

This work was supported by Research Grants of the Postgraduate Programme ‘Applications of Molecular Biology-Genetics. Diagnostic Biomarkers,’ code 3817 of the University of Thessaly, School of Health Sciences, Department of Biochemistry & Biotechnology.

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  1. Department of Biochemistry & Biotechnology, School of Health Sciences, University of Thessaly, 26, Ploutonos & Aeolou Str., 41221, Larissa, Greece

    Zaharoula Kyriakopoulou, Vaia Pliaka, Grigoris D. Amoutzias & Panayotis Markoulatos

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  1. Zaharoula Kyriakopoulou
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  2. Vaia Pliaka
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  3. Grigoris D. Amoutzias
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  4. Panayotis Markoulatos
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Correspondence to Panayotis Markoulatos.

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Kyriakopoulou, Z., Pliaka, V., Amoutzias, G.D. et al. Recombination among human non-polio enteroviruses: implications for epidemiology and evolution. Virus Genes 50, 177–188 (2015). https://doi.org/10.1007/s11262-014-1152-y

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  • DOI: https://doi.org/10.1007/s11262-014-1152-y

Keywords

  • Recombination
  • Enteroviruses
  • Evolution
  • Molecular epidemiology