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Susceptibility of muridae cell lines to ecotropic murine leukemia virus and the cationic amino acid transporter 1 viral receptor sequences: implications for evolution of the viral receptor

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Abstract

Ecotropic murine leukemia viruses (Eco-MLVs) infect mouse and rat, but not other mammalian cells, and gain access for infection through binding the cationic amino acid transporter 1 (CAT1). Glycosylation of the rat and hamster CAT1s inhibits Eco-MLV infection, and treatment of rat and hamster cells with a glycosylation inhibitor, tunicamycin, enhances Eco-MLV infection. Although the mouse CAT1 is also glycosylated, it does not inhibit Eco-MLV infection. Comparison of amino acid sequences between the rat and mouse CAT1s shows amino acid insertions in the rat protein near the Eco-MLV-binding motif. In addition to the insertion present in the rat CAT1, the hamster CAT1 has additional amino acid insertions. In contrast, tunicamycin treatment of mink and human cells does not elevate the infection, because their CAT1s do not have the Eco-MLV-binding motif. To define the evolutionary pathway of the Eco-MLV receptor, we analyzed CAT1 sequences and susceptibility to Eco-MLV infection of other several murinae animals, including the southern vole (Microtus rossiaemeridionalis), large Japanese field mouse (Apodemus speciosus), and Eurasian harvest mouse (Micromys minutus). Eco-MLV infection was enhanced by tunicamycin in these cells, and their CAT1 sequences have the insertions like the hamster CAT1. Phylogenetic analysis of mammalian CAT1s suggested that the ancestral CAT1 does not have the Eco-MLV-binding motif, like the human CAT1, and the mouse CAT1 is thought to be generated by the amino acid deletions in the third extracellular loop of CAT1.

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Acknowledgments

The VSV-G expression plasmid was kindly obtained from Dr. L. Chang through the AIDS Research and Reference Reagent Program, NIAID, NIH, USA. TELCeB6 cells were kindly provided by Dr. F. Cossett. We thank Ms. F. Tsujita, Ms. Y. Kobayashi, and Ms. M. Haraguchi for assistance. This study was partially supported by the Japan Society for the Promotion of Science.

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Authors and Affiliations

  1. Division of Cytokine Signaling, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan

    Katsura Kakoki, Mai Izumida, Yosuke Koizumi, Eri Honda, Hideki Hayashi, Toshifumi Matsuyama & Yoshinao Kubo

  2. Division of Biotechnology, Department of Bio-resources, Frontier Science Research Center, University of Miyazaki, Miyazaki, 889-1692, Japan

    Akio Shinohara, Goro Kato & Chihiro Koshimoto

  3. Department of Urology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523, Japan

    Katsura Kakoki, Tsukasa Igawa & Hideki Sakai

  4. Department of Plant and Animal Science, Faculty of Agriculture, University of Miyazaki, Miyazaki, 889-2192, Japan

    Tetsuo Morita

  5. Department of AIDS Research, Institute of Tropical Medicine, G-COE, Nagasaki University, Nagasaki, 852-8523, Japan

    Yoshinao Kubo

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  1. Katsura Kakoki
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  2. Akio Shinohara
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  13. Yoshinao Kubo
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Correspondence to Yoshinao Kubo.

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Kakoki, K., Shinohara, A., Izumida, M. et al. Susceptibility of muridae cell lines to ecotropic murine leukemia virus and the cationic amino acid transporter 1 viral receptor sequences: implications for evolution of the viral receptor. Virus Genes 48, 448–456 (2014). https://doi.org/10.1007/s11262-014-1036-1

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  • DOI: https://doi.org/10.1007/s11262-014-1036-1

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