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Molecular epizootiology of infectious bursal disease (IBD) in Korea

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Abstract

We conducted a molecular epizootiological study of infectious bursal disease (IBD) in Korea by analyzing 85 IBD viruses (IBDVs) obtained from vaccinated or unvaccinated flocks between 1980 and 2007. Phylogenetic analysis of the partial nucleotide sequence of the hypervariable region of the VP2 gene (nucleotides 661–1020) and pathogenicity tests revealed more genetic and phenotypic diversity of IBDV in Korea than has been reported previously. We showed that very virulent IBDVs (vvIBDVs) were already present in Korea in 1986. Moreover, vvIBDVs were repeatedly detected in Korean poultry that had been vaccinated, which casts doubt on the IBD vaccine programs. We also identified novel putative antigenic variant (AV)-like IBDV isolates on the basis of their antigenic indices and the presence of amino acid changes (P222S or P222T-A321D) that are known to affect the antigenicity of VP2. These observations suggest that future studies examining the efficacy of conventional vaccines against atrophy of the bursa of Fabricius and vvIBDV shedding may be useful. Moreover, it will be of interest to determine the prevalence of putative Korean antigenic variants and whether these strains exert immunosuppressive effects in vaccinated birds.

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References

  1. T.P. van den Berg, Avian Pathol. 29, 175–194 (2000)

    Article  CAS  Google Scholar 

  2. N.M. Ismail, Y.M. Saif, P.D. Moorhead, Avian Dis. 32, 757–759 (1988)

    Article  CAS  Google Scholar 

  3. C. Le Nouen, G. Rivallan, D. Toquin, P. Darlu, Y. Morin, V. Beven, C. de Boisseson, C. Cazaban, S. Comte, Y. Gardin, N. Eterradossi, J. Gen. Virol. 87, 209–216 (2006)

    Article  Google Scholar 

  4. Y. Wei, J. Li, J. Zheng, H. Xu, L. Li, L. Yu, Biochem. Biophys. Res. Commun. 350, 277–287 (2006)

    Article  CAS  Google Scholar 

  5. A.A. Azad, S.A. Barrett, K.J. Fahey, Virology 143, 35–44 (1985)

    Article  CAS  Google Scholar 

  6. U. Spies, H. Muller, H. Becht, Virus Res. 8, 127–140 (1987)

    Article  CAS  Google Scholar 

  7. M.M. Morgan, I.G. Macreadie, V.R. Harley, P.J. Hudson, A.A. Azad, Virology 163, 240–242 (1988)

    Article  CAS  Google Scholar 

  8. P.J. Hudson, N.M. McKern, B.E. Power, A.A. Azad, Nucleic Acids Res. 14, 5001–5012 (1986)

    Article  CAS  Google Scholar 

  9. A.A. Azad, M.N. Jagadish, M.A. Brown, P.J. Hudson, Virology 161, 145–152 (1987)

    Article  CAS  Google Scholar 

  10. M.N. Jagadish, V.J. Staton, P.J. Hudson, A.A. Azad, J. Virol. 62, 1084–1087 (1988)

    CAS  PubMed  PubMed Central  Google Scholar 

  11. H. Becht, H. Muller, H.K. Muller, J. Gen. Virol. 69(Pt 3), 631–640 (1988)

    Article  CAS  Google Scholar 

  12. K.J. Fahey, K. Erny, J. Crooks, J. Gen. Virol. 70(Pt 6), 1473–1481 (1989)

    Article  CAS  Google Scholar 

  13. C.D. Bayliss, U. Spies, K. Shaw, R.W. Peters, A. Papageorgiou, H. Muller, M.E. Boursnell, J. Gen. Virol. 71(Pt 6), 1303–1312 (1990)

    Article  CAS  Google Scholar 

  14. F. Coulibaly, C. Chevalier, I. Gutsche, J. Pous, J. Navaza, S. Bressanelli, B. Delmas, F.A. Rey, Cell 120, 761–772 (2005)

    Article  CAS  Google Scholar 

  15. T. Letzel, F. Coulibaly, F.A. Rey, B. Delmas, E. Jagt, A.A. van Loon, E. Mundt, J. Virol. 81, 12827–12835 (2007)

    Article  CAS  Google Scholar 

  16. A.S. Cosgrove, Avian Dis. 6, 385–389 (1962)

    Article  Google Scholar 

  17. G.C. Mohanty, A.P. Pandey, B.S. Rajya, Curr. Sci. 40, 181–184 (1971)

    Google Scholar 

  18. K. Hirai, S. Shimakura, E. Kawamoto, F. Taguchi, S.T. Kim, C.N. Chang, Y. Iritani, Avian Dis. 18, 50–57 (1974)

    Article  CAS  Google Scholar 

  19. G.A. Firth, Aust. Vet. J. 50, 128–130 (1974)

    Article  CAS  Google Scholar 

  20. P. Box, World Poultry, March 17–19, 1989

  21. S.A. Edgar, Y. Cho, Poult. Sci. 44, 1366 (1965)

    Google Scholar 

  22. N. Chettle, J.C. Stuart, P.J. Wyeth, Vet. Rec. 125, 271–272 (1989)

    Article  CAS  Google Scholar 

  23. T.P. van den Berg, M. Gonze, G. Meulemans, Avian Pathol. 20, 133–143 (1991)

    Article  CAS  Google Scholar 

  24. K. Zierenberg, H. Nieper, T.P. van den Berg, C.D. Ezeokoli, M. Voss, H. Muller, Arch. Virol. 145, 113–125 (2000)

    Article  CAS  Google Scholar 

  25. Y.O. Rhee, S.J. Kim, S.B. Kim, C.O. Choi, W.S. Jhun, K.S. Park, Nonsibogo 23, 136–142 (1981)

    Google Scholar 

  26. D.W. Lee, Master thesis, Seoul National University, 1993

  27. J.K. Rosenberger, S.S. Cloud, J. Gelb, E. Odor, S.E. Dohms, in Proceeding of the 20th National Meeting on Poultry Health and Condemnation, Delmarva Poultry Industry, Inc., Ocean City, MD, 94–101, 1985

  28. D.J. Jackwood, K.C. Cookson, S.E. Sommer-Wagner, H. Le Galludec, J.J. de Wit, Avian Dis. 50, 532–536 (2006)

    Article  CAS  Google Scholar 

  29. D. Ojkic, E. Martin, J. Swinton, B. Binnington, M. Brash, Avian Pathol. 36, 427–433 (2007)

    Article  CAS  Google Scholar 

  30. Y.C. Cao, W.S. Yeung, M. Law, Y.Z. Bi, F.C. Leung, B.L. Lim, Avian Dis. 42, 340–351 (1998)

    Article  CAS  Google Scholar 

  31. S.I. Sapats, J. Ignjatovic, Arch. Virol. 145, 773–785 (2000)

    Article  CAS  Google Scholar 

  32. A. Banda, P. Villegas, J. El-Attrache, Avian Dis. 47, 87–95 (2003)

    Article  CAS  Google Scholar 

  33. B.A. Jameson, H. Wolf, Comput. Appl. Biosci. 4, 181–186 (1988)

    CAS  PubMed  Google Scholar 

  34. S. Kumar, K. Tamura, M. Nei, Brief. Bioinform. 5, 150–163 (2004)

    Article  CAS  Google Scholar 

  35. M.D. Brown, P. Green, M.A. Skinner, J. Gen. Virol. 75(Pt 3), 675–680 (1994)

    Article  CAS  Google Scholar 

  36. L.J. Reed, H. Muench, Am. J. Hyg. 27, 493–497 (1938)

    Google Scholar 

  37. B. Lucio, S.B. Hitchner, Avian Dis. 23, 1037–1050 (1979)

    Article  CAS  Google Scholar 

  38. C.J. Kasanga, T. Yamaguchi, P.N. Wambura, A.D. Maeda-Machang’u, K. Ohya, H. Fukushi, Arch. Virol. 152, 783–790 (2007)

    Article  CAS  Google Scholar 

  39. H.M. Kwon, D.K. Kim, H.W. Seong, Korean J. Vet. Res. 39(3), 545–553 (1999)

    Google Scholar 

  40. N. Eterradossi, Paris: OIE, 75–82, 1995

  41. C.C. Hon, T.Y. Lam, A. Drummond, A. Rambaut, Y.F. Lee, C.W. Yip, F. Zeng, P.Y. Lam, P.T. Ng, F.C. Leung, J. Virol. 80, 8503–8509 (2006)

    Article  CAS  Google Scholar 

  42. A.A. Owoade, M.N. Mulders, J. Kohnen, W. Ammerlaan, C.P. Muller, Arch. Virol. 149, 653–672 (2004)

    Article  CAS  Google Scholar 

  43. B. Cisse, Doctoral Thesis in Veterinary Medicine, National School for Veterinary Medicine, Nantes, France, 1989

  44. N. Enterrodossi, C. Arnauld, F. Tekaia, D. Toquin, H. Le Coq, G. Rivallan, M. Guittet, J. Domenech, T.P. Van den Berg, M.A. Skinner, Avian Pathol. 28, 36–46 (1999)

    Article  Google Scholar 

  45. A. Banda, P. Villegas, Avian Dis. 48, 540–549 (2004)

    Article  Google Scholar 

  46. H.A. Wichman, M.R. Badgett, L.A. Scott, C.M. Boulianne, J.J. Bull, Science 285, 422–424 (1999)

    Article  CAS  Google Scholar 

  47. C.J. Kasanga, T. Yamaguchi, P.N. Wambura, H.M. Munang’andu, K. Ohya, H. Fukushi, Virus Genes 36, 521–529 (2008)

    Article  CAS  Google Scholar 

  48. M. Ogawa, T. Wakuda, T. Yamaguchi, K. Murata, A. Setiyono, H. Fukushi, K. Hirai, J. Vet. Med. Sci. 60, 1277–1279 (1998)

    Article  CAS  Google Scholar 

  49. D.P. Lana, C.E. Beisel, R.F. Silva, Virus Genes 6, 247–259 (1992)

    Article  CAS  Google Scholar 

  50. A. Akin, C.C. Wu, T.L. Lin, J. Virol. Methods 82, 55–61 (1999)

    Article  CAS  Google Scholar 

  51. H.G. Heine, M. Haritou, P. Failla, K. Fahey, A. Azad, J. Gen. Virol. 72(Pt 8), 1835–1843 (1991)

    Article  CAS  Google Scholar 

  52. L.H. Parede, S. Sapats, G. Gould, M. Rudd, S. Lowther, J. Ignjatovic, Avian Pathol. 32, 511–518 (2003)

    Article  CAS  Google Scholar 

  53. D. Schnitzler, F. Bernstein, H. Muller, H. Becht, J. Gen. Virol. 74(Pt 8), 1563–1571 (1993)

    Article  CAS  Google Scholar 

  54. T.P. Van den Berg, M. Gonze, D. Morales, G. Meulemans, Avian Pathol. 25, 751–768 (1996)

    Article  CAS  Google Scholar 

  55. T.V. Dormitorio, J.J. Giambrone, L.W. Duck, Avian Dis. 41, 36–44 (1997)

    Article  CAS  Google Scholar 

  56. J. Liu, J. Zhou, J. Kwang, Virus Genes 24, 135–147 (2002)

    Article  Google Scholar 

  57. Y.M. Saif, in 19th National Meeting on Poultry Health and Condemnations, Ocean City, MD, 105–107, 1984

  58. N.M. Ismail, Y.M. Saif, W.L. Wigle, G.B. Havenstein, C. Jackson, Avian Dis. 34, 141–145 (1990)

    Article  CAS  Google Scholar 

  59. E. Mundt, V.N. Vakharia, Proc. Natl Acad. Sci. USA 93, 11131–11136 (1996)

    Article  CAS  Google Scholar 

  60. K. Domanska, T. Mato, G. Rivallan, K. Smietanka, Z. Minta, C. de Boisseson, D. Toquin, B. Lomniczi, V. Palya, N. Eterradossi, Arch. Virol. 149, 465–480 (2004)

    Article  CAS  Google Scholar 

  61. P.D. Lukert, Y.M. Saif, in Diseases of Poultry, 11th edn., ed. by Y.M. Saif (Iowa State Press, Ames, IA, 2003), pp. 161–179

    Google Scholar 

  62. M.M. Hoque, A.R. Omar, L.K. Chong, M. Hair-Bejo, I. Aini, Avian Pathol. 30, 369–380 (2001)

    Article  CAS  Google Scholar 

Download references

Acknowledgment

This study was partially supported by the Technology Development Program of the Ministry of Agriculture and Forestry, Korea.

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Authors and Affiliations

  1. Avian Disease Division, National Veterinary Research and Quarantine Service, Anyang, Gyeonggi-Do, 430-824, Korea

    Woo-Jin Jeon, Kang-Seuk Choi, Eun-Kyoung Lee & Jun-Hun Kwon

  2. Laboratory of Avian Diseases, College of Veterinary Medicine, Seoul National University, Seoul, 151-742, Korea

    Dong-Woo Lee, Sang-Ho Cha & Jae-Hong Kim

  3. Zoonotic Disease Institute (ZooDI), College of Veterinary Medicine, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Korea

    Sun-Hee Cho, Jae-Hong Kim & Hyuk-Joon Kwon

  4. Department of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul, 151-742, Korea

    Yeo-sung Yoon

  5. BioPOA Co., Suwon, Korea

    Sun-Joong Kim

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  1. Woo-Jin Jeon
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Correspondence to Hyuk-Joon Kwon.

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Jeon, WJ., Choi, KS., Lee, DW. et al. Molecular epizootiology of infectious bursal disease (IBD) in Korea. Virus Genes 39, 342–351 (2009). https://doi.org/10.1007/s11262-009-0394-6

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