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Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors

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Abstract

Mast cell count (MCC) in 45 dogs with cutaneous hemangioma (HA, n = 12), hemangiosarcoma (HSA, n = 12), mammary adenoma (AD, n = 9) and mammary adenocarcinoma (AC, n = 12) was made using Toluidine blue stained sections. Antibodies against endothelial cell markers, Factor VIII and VEGF were used to visualize and determine the hot spot micro-vessel density (MVD). Total MCC and MCC along the invasive edges were significantly higher (p < 0.001) in canine mammary AC than in AD. The total MCC did not significantly differ (p > 0.05), in HSAs (8.6 ± 3.3) than in HAs (5.5 ± 2.8). There is a positive correlation (r = 0.14) between the hot spot MCC and MVD in mammary AC, although not significant (p = 0.3172), indicating that mast cells are associated with angiogenesis in canine mammary AC. This study suggests that mast cells may play an important role in neovascularization of canine cutaneous vascular and mammary neoplasms. Detailed studies encompassing correlation of MCC and MVD with clinical outcomes and prognosis in these neoplasms are recommended.

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Authors and Affiliations

  1. Department of Pathology, Tifton Veterinary Diagnostic and Investigational Laboratory, College of Veterinary Medicine, University of Georgia, 43 Brighton Rd, Tifton, GA, 31793, USA

    Moges Woldemeskel & Sreekumari Rajeev

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  1. Moges Woldemeskel
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  2. Sreekumari Rajeev
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Correspondence to Moges Woldemeskel.

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Woldemeskel, M., Rajeev, S. Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors. Vet Res Commun 34, 153–160 (2010). https://doi.org/10.1007/s11259-010-9341-1

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