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Pharmacokinetic behaviour of enrofloxacin and its metabolite ciprofloxacin after subcutaneous administration in cattle

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Abstract

This study compared pharmacokinetic profiles in cattle dosed subcutaneously with two different formulations of enrofloxacin (5% and 10%) at a dose of 5 mg/kg. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by a HPLC/u.v. method. The pharmacokinetic parameters of enrofloxacin and its metabolite were similar in both injectable formulations. Enrofloxacin peak plasma concentration (5%: 0.73 ± 0.32; 10%: 0.60 ± 0.14 μg/mL) was reached at 1.21 ± 0.52 and 1.38 ± 0.52 h to 5 and 10%, respectively. The terminal half-live and area under curve were 2.34 ± 0.46 and 2.59 ± 0.46 h, and 3.09 ± 0.81 and 2.93 ± 0.58 μg·h/mL, to 5 and 10%, respectively. The AUC/MIC90 and Cmax/MIC90 ratios for both formulations exceed the proposed threshold values for optimized efficacy and minimized resistance development whilst treating infections or septicaemia caused by P. multocida and E. coli.

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Acknowledgments

The authors thank Mr. Mariano Díaz-Flores for his technical assistance. Thanks to the staff of the Biblioteca de la Facultad de Veterinaria (BUCM) for their invaluable help. This study was supported by a grant from the Bayer Health Care, AG (348/2001 Art. 83 LRU/UCM). Special thanks to Mr Enrique Rierola, from Química Farmacéutica Bayer, S.A. (Barcelona, Spain) and Ms. Isabel Uriarte Inchausti (DVM).

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Authors and Affiliations

  1. Cátedra de Farmacología, Dpto. Farmacología y Toxicología, Facultad de Veterinaria, Universidad Complutense de Madrid, Ciudad Universitaria, 28040, Madrid, Spain

    J. J. de Lucas, M. I. San Andrés & F. González

  2. Bayer HealthCare AG, Animal Health, 51368, Leverkusen, Germany

    R. Froyman

  3. Departamento de Toxicología y Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda/ Puerta de Hierro s/n, Ciudad Universitaria, 28040, Madrid, Spain

    C. Rodríguez

  4. Cátedra de Farmacología, Departamento de Toxicología y Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040, Madrid, Spain

    C. Rodríguez

Authors
  1. J. J. de Lucas
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  2. M. I. San Andrés
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  3. F. González
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  4. R. Froyman
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  5. C. Rodríguez
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Corresponding author

Correspondence to C. Rodríguez.

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de Lucas, J.J., San Andrés, M.I., González, F. et al. Pharmacokinetic behaviour of enrofloxacin and its metabolite ciprofloxacin after subcutaneous administration in cattle. Vet Res Commun 32, 275–279 (2008). https://doi.org/10.1007/s11259-008-9037-y

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  • DOI: https://doi.org/10.1007/s11259-008-9037-y

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