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Ivermectin in Senegalese Peulh Sheep: Influence of Sex on Plasma Disposition

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Abstract

The plasma disposition kinetics of ivermectin following a single subcutaneous administration of 0.2 mg/kg was investigated in male and female Senegalese Peulh sheep. Ten clinically healthy animals (5 males and 5 females) weighing 38–45 kg were used in this trial. Blood samples were collected by jugular puncture at different times between 0.5 h and 30 days post treatment. After plasma extraction and derivatization, samples were analysed by HPLC with fluorescence detection. Computerized kinetic analysis was carried out and mean parameters were statistically compared with the Mann–Whitney U-test. The area under the concentration–time curve (AUC) was significantly higher (p < 0.0027) in females than in males. Although the differences in maximum concentration (C max), mean residence time (MRT) and half-life of elimination (t 1/2el) between males and females did not achieve statistical significance, values tended to be higher in females. Sex differences may be parallel with the level of storage in fat. Further investigations are required to improve the use of ivermectin in Senegalese sheep and findings may be used to predict optimal anthelmintic strategies for management of African species depending on the parasites present in a production system.

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Abbreviations

AUC:

area under the plasma concentration–time curve

AUMC:

area under the moment curve

C max :

observed peak plasma concentration

HPLC:

high-performance liquid chromatography

k a :

constant rate of absorption

k 10 :

constant of elimination

MRT:

mean residence time

SPE:

solid-phase extraction

t max :

time to reach C max

(t 1/2k a):

half-life of absorption

t 1/2el :

half-life of elimination

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Authors and Affiliations

  1. Ecole Inter-Etats des Sciences et Médecine Vétérinaires, Dakar Fann, Sénégal

    T. Bengone Ndong, Y. Kane & E. H. M. Diouf

  2. Laboratoire de Pharmacologie–Toxicologie, INRA UR 66, Toulouse, France

    M. Alvinerie

Authors
  1. T. Bengone Ndong
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  2. Y. Kane
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  3. E. H. M. Diouf
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  4. M. Alvinerie
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Correspondence to M. Alvinerie.

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Ndong, T.B., Kane, Y., Diouf, E.H.M. et al. Ivermectin in Senegalese Peulh Sheep: Influence of Sex on Plasma Disposition. Vet Res Commun 31, 739–747 (2007). https://doi.org/10.1007/s11259-007-3522-6

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  • DOI: https://doi.org/10.1007/s11259-007-3522-6

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