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Short Communication: Pharmacokinetics of an Ampicillin–Sulbactam (2:1) Combination after Intravenous and Intramuscular Administration to Chickens

  • Pharmacology
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Abbreviations

AUC:

area under the plasma concentration–time curve from zero to infinity

Cl:

total body clearance of drug from the plasma

Cl/F:

body clearance after intramuscular administration

C max :

peak or maximum plasma concentration following drug administration

D :

dose administered

F :

fraction of the administered dose systemically available (bioavailability)

k a :

absorption rate constant (first order)

λ1:

largest (fastest) disposition (= hybrid) rate constant

λz:

smallest (slowest) disposition (= hybrid) rate constant

MAT:

mean absorption time

MIC:

minimum inhibitory concentration

MRT:

mean residence time

t½ a:

absorption half-life

t½λ1:

disposition half-life associated with the initial slope (λ1) of a semilogarithmic concentration–time curve

t½ λ z :

elimination half-life associated with the terminal slope (λ z ) of a semilogarithmic concentration–time curve

t max :

time to reach peak or maximum plasma concentration following drug administration

V ss :

apparent volume of distribution at steady state

V z :

apparent volume of distribution calculated by the area method

References

  • Anadón, A., Martínez-Larrañaga, M.R., Diaz, M.J., Bringas, P., Fernández, M.C., Martínez, M.A. and Fernández-Cruz, M.L., 1996. Pharmacokinetics of amoxicillin in broiler chickens. Avian Pathology, 25, 449–458

    Google Scholar 

  • Atef, M., El-Gendi, A.Y., El-Sayed H.G. and Amer A.M., 1986. Blood and tissue concentrations of ampicillin in chickens. Deutsche Tierarztliche Wochenschrift, 93, 110–112

    CAS  PubMed  Google Scholar 

  • Blim, R.A., Kohli, R.K., Harrison, N.J. and Schentag, J.J., 1989. Pharmacokinetics of ampicillin (2.0 grams) and sulbactam (1.0 grams) coadministered to subjects with normal and abnormal renal function and with end-stage renal disease on hemodialysis. Antimicrobial Agents and Chemotherapy, 9, 1470–1476

    Google Scholar 

  • Carceles, C.M., Vicente, M.S. and Escudero, E., 1995. Pharmacokinetics of amoxicillin-clavulanic acid combination after intravenous and intramuscular administration to turkeys and chickens. Avian Pathology, 24, 643–652

    CAS  Google Scholar 

  • Craig, W.A., 2001. Does the dose matter? Clinical Infectious Disease, 33(supplement 3), S233–S237

    CAS  Google Scholar 

  • Dorrestein, G.M., Van Gogh, H., Rinzema, J.D. and Buitelaar, M.N., 1986. Bioavailability and pharmacokinetics of ampicillin and amoxicillin from tablets, capsules and long-acting preparations in the homing pigeon (Columba livia). Journal of Veterinary Pharmacology and Therapeutics, 9, 394–401

    CAS  PubMed  Google Scholar 

  • Dorrestein, G.M., Van Gogh, H., Rinzema, J.D. and Buitelaar, M.N., 1987. Comparative study of ampicillin after intravenous, intramuscular and oral administration in homing pigeons (Columba livia). Research in Veterinary Science, 42, 343–348

    CAS  PubMed  Google Scholar 

  • FDA/USDA/CDC. NARMS, 1998. National Antimicrobial Resistance Monitoring System – Enteric Bacteria (NARMS-EB) Veterinary Isolates Annual Report 1998. [Online] http://www.ars-grin.gov/ars/SoAtlantic/Athens/arru/narms_1998/1998_figure_12.pdf

  • Fernández-Varón, E., Cárceles, C.M., Espuny, A., Marín, P. and Escudero, E., 2004. Pharmacokinetics of an ampicillin-sulbactam (2:1) combination in Turkeys. American Journal of Veterinary Research, 65, 1658–1663

    PubMed  Google Scholar 

  • Loo, J.C.K. and Riegelman, S., 1968. New method for calculating the intrinsic absorption rate of drugs. Journal of Pharmaceutical Science, 57, 918–928

    CAS  Google Scholar 

  • Prescott, J.F. and Baggot, J.D., 1993. Beta-lactam antibiotics: penam penicillins. In: J.F. Prescot and J.D. Baggot, (eds), Antimicrobial Therapy in Veterinary Medicine, 2nd edn, (Iowa State University Press, Ames, IA) 83–93

    Google Scholar 

  • Rudrik, J.T. and Bawdon, R.E., 1981. Determination of penicillinase resistant penicillins in plasma using high pressure liquid chromatography. Journal of Liquid Chromathography, 4, 1525–1545

    CAS  Google Scholar 

  • Shumaker, R.C., 1986. PKCALC: a basic interactive computer program for statistical and pharmacokinetic analysis of data. Drug Metabolism Reviews, 17, 331–348

    CAS  PubMed  Google Scholar 

  • Wagner, J.G., 1982. Farmacocinética Clínica, (Reverté, Barcelona)

    Google Scholar 

  • Yamaoka, K., Nakagawa, T. and Uno, T., 1978. Application of Akaike's Information Criterion (AIC) in the evaluation of linear pharmacokinetic equations. Journal of Pharmacokinetics and Biopharmaceutics, 6, 165–175

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, 30.071, Murcia, Spain

    E. Fernández-Varón, E. Escudero, P. Marín & C. M. Cárceles

Authors
  1. E. Fernández-Varón
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  2. E. Escudero
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  3. P. Marín
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  4. C. M. Cárceles
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Correspondence to E. Fernández-Varón.

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Fernández-Varón, E., Escudero, E., Marín, P. et al. Short Communication: Pharmacokinetics of an Ampicillin–Sulbactam (2:1) Combination after Intravenous and Intramuscular Administration to Chickens. Vet Res Commun 30, 285–291 (2006). https://doi.org/10.1007/s11259-006-3248-x

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  • DOI: https://doi.org/10.1007/s11259-006-3248-x

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