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Triglyceride-glucose index predicts major adverse cardiovascular events in patients with chronic kidney disease

  • Nephrology - Original Paper
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Abstract

Background and purpose

Triglyceride-glucose (TyG) index has been regarded as a reliable surrogate marker of insulin resistance for predicting cardiovascular outcomes. The current study aimed to explore the associations between TyG index with major adverse cardiovascular events (MACE) in patients with chronic kidney disease (CKD).

Methods/patients

13,517 patients with chronic kidney disease (CKD) from the Kailuan study were included. Patients were divided into quartiles according to the TyG index. The outcomes were MACE, including acute myocardial infarction (AMI) and ischemic stroke (IS). The association between TyG index and the risk of MACE was analyzed by Cox regression models.

Results

During 13.87-year follow-up, a total 1356 MACEs occurred. Multivariable Cox proportional-hazards analyses showed that a higher TyG index quartile was associated with an elevated risk of MACE.

Conclusions

TyG index is significantly related to MACE in patients with CKD. TyG index can be regarded as a novel predictor of MACE for patients with CKD.

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Data availability

The data that support the findings of this study are available on request from the corresponding author.

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Funding

This research was supported by the key scientific research project of health commission of Hebei province, PR China. Project No.: 20231775.

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Authors and Affiliations

  1. Department of Internal Medicine, Wenfeng District Xiguan Subdistrict Office Community Health Center, Anyang, China

    Kangbo Li

  2. Hebei Medical University, Shijiazhuang, China

    Qiqi Hou

  3. School of Clinical Medicine, Xiangnan University, Chenzhou, China

    Xinyi Li

  4. Catheterization Unit, Tangshan Gongren Hospital, Tangshan, China

    Liying Tian

  5. Department of Cardiology, Tangshan Gongren Hospital, Tangshan, China

    Liyan Wang & Quanle Han

  6. Department of Cardiology, Kailuan General Hospital, Tangshan, China

    Shouling Wu

Authors
  1. Kangbo Li
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  5. Liyan Wang
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Correspondence to Quanle Han.

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Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Ethical approval

The Kailuan study is a prospective study to investigate the risk factors for cardiovascular and cerebrovascular disease in the Tangshan city, China. The protocol of Kailuan study has been approved by the ethics committee of Kailuan hospital, and registrated in the Chinese clinical trial registry (ChiCTR-TNRC-11001489).

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Li, K., Hou, Q., Li, X. et al. Triglyceride-glucose index predicts major adverse cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol (2024). https://doi.org/10.1007/s11255-024-04005-9

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