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The role of PI3K/Akt signaling pathway in chronic kidney disease

  • Nephrology - Review
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Abstract

Chronic kidney disease (CKD), including chronic glomerulonephritis, IgA nephropathy and diabetic nephropathy, are common chronic diseases characterized by structural damage and functional decline of the kidneys. The current treatment of CKD is symptom relief. Several studies have reported that the phosphatidylinositol 3 kinases (PI3K)/protein kinase B (Akt) signaling pathway is a pathway closely related to the pathological process of CKD. It can ameliorate kidney damage by inhibiting this signal pathway which is involved with inflammation, oxidative stress, cell apoptosis, epithelial mesenchymal transformation (EMT) and autophagy. This review highlights the role of activating or inhibiting the PI3K/Akt signaling pathway in CKD-induced inflammatory response, apoptosis, autophagy and EMT. We also summarize the latest evidence on treating CKD by targeting the PI3K/Akt pathway, discuss the shortcomings and deficiencies of PI3K/Akt research in the field of CKD, and identify potential challenges in developing these clinical therapeutic CKD strategies, and provide appropriate solutions.

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Funding

This study was funded by Key Program of Hebei Natural Science foundation of traditional Chinese Medicine, H2022423351.

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  1. Hongshuang Wang and Lanjun Gao contributed equally.

Authors and Affiliations

  1. Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, 050091, China

    Hongshuang Wang, Lanjun Gao, Chenchen Zhao, Fang Fang & Jiazhi Liu

  2. Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns Research, Shijiazhuang, 050091, China

    Zheng Wang, Yan Zhong & Xiangting Wang

  3. Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, 050200, China

    Zheng Wang & Yan Zhong

Authors
  1. Hongshuang Wang
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  2. Lanjun Gao
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  3. Chenchen Zhao
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  4. Fang Fang
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  5. Jiazhi Liu
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  6. Zheng Wang
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  7. Yan Zhong
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  8. Xiangting Wang
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Contributions

XTW, YZ, and HSW contributed to the study idea and study design. LJG, FF, JZL, CCZ and HSW contributed to the literature search. HSW and ZW performed the literature summary. XTW and YZ provided supervision and guidance.

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Correspondence to Yan Zhong or Xiangting Wang.

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Wang, H., Gao, L., Zhao, C. et al. The role of PI3K/Akt signaling pathway in chronic kidney disease. Int Urol Nephrol (2024). https://doi.org/10.1007/s11255-024-03989-8

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